SRR656745
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- SPERMATOGENESIS+0.204
- HEME_METABOLISM+0.107
- PROTEIN_SECRETION+0.100
- KRAS_SIGNALING_DN+0.096
- PANCREAS_BETA_CELLS+0.070
- ANDROGEN_RESPONSE+0.055
- MITOTIC_SPINDLE+0.023
- UV_RESPONSE_DN+0.009
- OXIDATIVE_PHOSPHORYLATION-0.014
- PEROXISOME-0.075
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.497
- NOTCH_SIGNALING-0.482
- IL6_JAK_STAT3_SIGNALING-0.463
- ALLOGRAFT_REJECTION-0.458
- INTERFERON_GAMMA_RESPONSE-0.433
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.429
- MYC_TARGETS_V2-0.399
- TNFA_SIGNALING_VIA_NFKB-0.391
- TGF_BETA_SIGNALING-0.370
- APOPTOSIS-0.355
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
8 twins match this tumor's tissue · 2 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR659555 | GTEX | — | 0.948 |
| 2 | SRR663753 | GTEX | — | 0.948 |
| 3 | SRR820623 | GTEX | — | 0.944 |
| 4 | BS_N6NE6B3W | pilocytic astrocytoma | — | 0.941 |
| 5 | SRR658129 | GTEX | — | 0.940 |
| 6 | SRR655649 | GTEX | — | 0.928 |
| 7 | SRR613090 | GTEX | — | 0.926 |
| 8 | SRR660626 | GTEX | — | 0.926 |
| 9 | SRR1341365 | GTEX | — | 0.921 |
| 10 | BS_ZRM0W01M | low-grade glioma | — | 0.917 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 8 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| SPERMATOGENESIS | 0.204 | Inavolisib | — uncovered |
| HEME_METABOLISM | 0.107 | Temsirolimus | — uncovered |
| PROTEIN_SECRETION | 0.100 | Remibrutinib | — uncovered |
| KRAS_SIGNALING_DN | 0.096 | Remibrutinib | — uncovered |
| PANCREAS_BETA_CELLS | 0.070 | Cobimetinib | — uncovered |
| ANDROGEN_RESPONSE | 0.055 | Inavolisib | — uncovered |
| MITOTIC_SPINDLE | 0.023 | Inavolisib | — uncovered |
| UV_RESPONSE_DN | 0.009 | Inavolisib | — uncovered |