Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

aMVAC.P_013_TURBT_S232

7bc337ac-e039-5457-940a-da0f38eb5bc2

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1SRR11296875
colon-landscapes@1
0.853
2R108
bladder-landscape@3
0.822
3TCGA-UY-A78M-01A-21R-A352-07
bladder-landscape@3
0.812
4TCGA-P3-A5Q6-01A-11R-A28V-07
head-neck@1
0.811
5TCGA-UF-A71A-01A-22R-A34R-07
head-neck@1
0.806
6SRR35579843
breast-umap@18
B0.799
7add96e53-1114-4364-979b-641665d16629
melanoma-umap@29
0.799
8SRR8942944
bladder-landscape@3
0.796
9R308
bladder-landscape@3
0.787
10fa32f303-025b-40d2-a9b0-25bc7622c27e
colon-landscapes@1
0.780

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 28 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
MYC_TARGETS_V20.650Idelalisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.480Remibrutinib— uncovered
MYC_TARGETS_V10.440Inavolisib— uncovered
HYPOXIA0.370Idelalisib— uncovered
GLYCOLYSIS0.310Inavolisib— uncovered
ADIPOGENESIS0.280Inavolisib— uncovered
FATTY_ACID_METABOLISM0.270Inavolisib— uncovered
CHOLESTEROL_HOMEOSTASIS0.250Remibrutinib— uncovered
MTORC1_SIGNALING0.240Inavolisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.180Inavolisib— uncovered
DNA_REPAIR0.170Idelalisib— uncovered
NOTCH_SIGNALING0.170Inavolisib— uncovered
P53_PATHWAY0.170Idelalisib— uncovered
PEROXISOME0.170Idelalisib— uncovered
APICAL_SURFACE0.160Temsirolimus— uncovered
ESTROGEN_RESPONSE_EARLY0.140Inavolisib— uncovered
ESTROGEN_RESPONSE_LATE0.130Idelalisib— uncovered
KRAS_SIGNALING_DN0.100Remibrutinib— uncovered
BILE_ACID_METABOLISM0.070Inavolisib— uncovered
WNT_BETA_CATENIN_SIGNALING0.070Inavolisib— uncovered