Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-DK-A3IV-01A-22R-A21D-07

7cc4935f-c9fb-5bb3-aa0b-fa544ce4201f

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
overall_survival_months
9.658344284
os_event
true
sex
Male

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • INTERFERON_ALPHA_RESPONSE+0.570
  • INTERFERON_GAMMA_RESPONSE+0.460
  • G2M_CHECKPOINT+0.340
  • MITOTIC_SPINDLE+0.310
  • E2F_TARGETS+0.300
  • PROTEIN_SECRETION+0.300
  • ALLOGRAFT_REJECTION+0.180
  • PI3K_AKT_MTOR_SIGNALING+0.130
  • HEME_METABOLISM+0.120
  • ANDROGEN_RESPONSE+0.090

Top 10 suppressed

  • EPITHELIAL_MESENCHYMAL_TRANSITION-0.680
  • ANGIOGENESIS-0.620
  • HEDGEHOG_SIGNALING-0.440
  • MYOGENESIS-0.440
  • HYPOXIA-0.430
  • OXIDATIVE_PHOSPHORYLATION-0.410
  • COAGULATION-0.370
  • APICAL_JUNCTION-0.360
  • WNT_BETA_CATENIN_SIGNALING-0.360
  • PANCREAS_BETA_CELLS-0.340

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
117-071pB9_FFPE
bladder-landscape@3
0.881
2SRR8613806
breast-umap@18
D0.865
3TCGA-78-7143-01A-11R-2039-07
lung-landscapes@6
cohortA10.855
4TCGA-95-7947-01A-11R-2187-07
lung-landscapes@6
cohortA10.818
5s0122212
melanoma-umap@29
0.815
6aMVAC.P_006_TURBT_S224
bladder-landscape@3
0.814
7SRR10899995
melanoma-umap@29
0.812
8TCGA-S3-A6ZF-01A-32R-A32P-07
breast-umap@18
B0.811
96b375859-116e-4a5e-b5b4-994a56cc9a75
melanoma-umap@29
0.810
10ERR2208907
melanoma-umap@29
0.805

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 13 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
INTERFERON_ALPHA_RESPONSE0.570Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.460Idelalisib— uncovered
G2M_CHECKPOINT0.340Inavolisib— uncovered
MITOTIC_SPINDLE0.310Inavolisib— uncovered
E2F_TARGETS0.300Inavolisib— uncovered
PROTEIN_SECRETION0.300Remibrutinib— uncovered
ALLOGRAFT_REJECTION0.180Idelalisib— uncovered
PI3K_AKT_MTOR_SIGNALING0.130Inavolisib— uncovered
HEME_METABOLISM0.120Temsirolimus— uncovered
ANDROGEN_RESPONSE0.090Inavolisib— uncovered
IL6_JAK_STAT3_SIGNALING0.090Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.060Idelalisib— uncovered
IL2_STAT5_SIGNALING0.010Idelalisib— uncovered