SRR1431183
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- OXIDATIVE_PHOSPHORYLATION+0.518
- PROTEIN_SECRETION+0.331
- REACTIVE_OXYGEN_SPECIES_PATHWAY+0.257
- CHOLESTEROL_HOMEOSTASIS+0.254
- MTORC1_SIGNALING+0.238
- PANCREAS_BETA_CELLS+0.191
- FATTY_ACID_METABOLISM+0.179
- PEROXISOME+0.176
- SPERMATOGENESIS+0.149
- MYC_TARGETS_V1+0.144
Top 10 suppressed
- IL6_JAK_STAT3_SIGNALING-0.480
- TNFA_SIGNALING_VIA_NFKB-0.444
- INTERFERON_GAMMA_RESPONSE-0.381
- INTERFERON_ALPHA_RESPONSE-0.371
- ANGIOGENESIS-0.325
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.324
- INFLAMMATORY_RESPONSE-0.313
- G2M_CHECKPOINT-0.303
- TGF_BETA_SIGNALING-0.303
- E2F_TARGETS-0.285
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
9 twins match this tumor's tissue · 1 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1368772 | GTEX | — | 0.910 |
| 2 | SRR657683 | GTEX | — | 0.907 |
| 3 | BS_09R7GDA7 | Embryonal tumors | — | 0.905 |
| 4 | SRR1386818 | GTEX | — | 0.896 |
| 5 | SRR660969 | GTEX | — | 0.893 |
| 6 | SRR657127 | GTEX | — | 0.880 |
| 7 | SRR1420984 | GTEX | — | 0.878 |
| 8 | SRR814967 | GTEX | — | 0.874 |
| 9 | SRR2167030 | GTEX | — | 0.873 |
| 10 | SRR1340508 | GTEX | — | 0.872 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 16 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| OXIDATIVE_PHOSPHORYLATION | 0.518 | Remibrutinib | — uncovered |
| PROTEIN_SECRETION | 0.331 | Remibrutinib | — uncovered |
| REACTIVE_OXYGEN_SPECIES_PATHWAY | 0.257 | Inavolisib | — uncovered |
| CHOLESTEROL_HOMEOSTASIS | 0.254 | Remibrutinib | — uncovered |
| MTORC1_SIGNALING | 0.238 | Inavolisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.191 | Cobimetinib | — uncovered |
| FATTY_ACID_METABOLISM | 0.179 | Inavolisib | — uncovered |
| PEROXISOME | 0.176 | Idelalisib | — uncovered |
| SPERMATOGENESIS | 0.149 | Inavolisib | — uncovered |
| MYC_TARGETS_V1 | 0.144 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.140 | Remibrutinib | — uncovered |
| ANDROGEN_RESPONSE | 0.138 | Inavolisib | — uncovered |
| ADIPOGENESIS | 0.092 | Inavolisib | — uncovered |
| UV_RESPONSE_UP | 0.047 | Idelalisib | — uncovered |
| GLYCOLYSIS | 0.042 | Inavolisib | — uncovered |
| PI3K_AKT_MTOR_SIGNALING | 0.037 | Inavolisib | — uncovered |