SRR1466871
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- INTERFERON_ALPHA_RESPONSE+0.541
- CHOLESTEROL_HOMEOSTASIS+0.467
- REACTIVE_OXYGEN_SPECIES_PATHWAY+0.457
- TNFA_SIGNALING_VIA_NFKB+0.449
- INTERFERON_GAMMA_RESPONSE+0.438
- INFLAMMATORY_RESPONSE+0.412
- IL6_JAK_STAT3_SIGNALING+0.401
- MTORC1_SIGNALING+0.393
- UNFOLDED_PROTEIN_RESPONSE+0.357
- P53_PATHWAY+0.355
Top 10 suppressed
- E2F_TARGETS-0.343
- MITOTIC_SPINDLE-0.301
- G2M_CHECKPOINT-0.300
- PROTEIN_SECRETION-0.160
- WNT_BETA_CATENIN_SIGNALING-0.138
- SPERMATOGENESIS-0.083
- HEME_METABOLISM-0.047
- NOTCH_SIGNALING-0.033
- BILE_ACID_METABOLISM-0.032
- UV_RESPONSE_DN+0.014
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
8 twins match this tumor's tissue · 2 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1347688 | GTEX | — | 0.905 |
| 2 | SRR1335688 | GTEX | — | 0.901 |
| 3 | SRR1331579 | GTEX | — | 0.897 |
| 4 | BS_MBSTWZA6 | pilocytic astrocytoma | — | 0.896 |
| 5 | SRR1374414 | GTEX | — | 0.896 |
| 6 | SRR1440356 | GTEX | — | 0.895 |
| 7 | SRR820133 | GTEX | — | 0.892 |
| 8 | SRR1445514 | GTEX | — | 0.891 |
| 9 | BS_9BJARSX3 | pleomorphic xanthoastrocytoma(PXA) | — | 0.890 |
| 10 | 65DAB913-D39C-4AC4-BB1C-10E58914571F | — | — | 0.889 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 41 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| INTERFERON_ALPHA_RESPONSE | 0.541 | Inavolisib | — uncovered |
| CHOLESTEROL_HOMEOSTASIS | 0.467 | Remibrutinib | — uncovered |
| REACTIVE_OXYGEN_SPECIES_PATHWAY | 0.457 | Inavolisib | — uncovered |
| TNFA_SIGNALING_VIA_NFKB | 0.449 | Inavolisib | — uncovered |
| INTERFERON_GAMMA_RESPONSE | 0.438 | Idelalisib | — uncovered |
| INFLAMMATORY_RESPONSE | 0.412 | Idelalisib | — uncovered |
| IL6_JAK_STAT3_SIGNALING | 0.401 | Inavolisib | — uncovered |
| MTORC1_SIGNALING | 0.393 | Inavolisib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.357 | Idelalisib | — uncovered |
| P53_PATHWAY | 0.355 | Idelalisib | — uncovered |
| COMPLEMENT | 0.311 | Inavolisib | — uncovered |
| UV_RESPONSE_UP | 0.304 | Idelalisib | — uncovered |
| XENOBIOTIC_METABOLISM | 0.298 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_LATE | 0.282 | Idelalisib | — uncovered |
| EPITHELIAL_MESENCHYMAL_TRANSITION | 0.280 | Inavolisib | — uncovered |
| COAGULATION | 0.266 | Binimetinib | — uncovered |
| HYPOXIA | 0.258 | Idelalisib | — uncovered |
| FATTY_ACID_METABOLISM | 0.254 | Inavolisib | — uncovered |
| KRAS_SIGNALING_UP | 0.250 | Inavolisib | — uncovered |
| APOPTOSIS | 0.244 | Idelalisib | — uncovered |