6e0c14ea-3eb3-424a-bc12-fb127ac1a777
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Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
- age_years
- 85
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- INTERFERON_ALPHA_RESPONSE+0.420
- NOTCH_SIGNALING+0.400
- IL6_JAK_STAT3_SIGNALING+0.370
- INTERFERON_GAMMA_RESPONSE+0.370
- BILE_ACID_METABOLISM+0.330
- OXIDATIVE_PHOSPHORYLATION+0.270
- APICAL_SURFACE+0.260
- ALLOGRAFT_REJECTION+0.250
- WNT_BETA_CATENIN_SIGNALING+0.240
- KRAS_SIGNALING_DN+0.220
Top 10 suppressed
- E2F_TARGETS-0.510
- G2M_CHECKPOINT-0.490
- MYC_TARGETS_V1-0.460
- MYC_TARGETS_V2-0.430
- UNFOLDED_PROTEIN_RESPONSE-0.360
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.330
- MITOTIC_SPINDLE-0.290
- MTORC1_SIGNALING-0.270
- PROTEIN_SECRETION-0.270
- UV_RESPONSE_DN-0.250
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
5 twins match this tumor's tissue · 5 come from a different tissue of origin ← cross-tissue dominant
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1419148 | GTEX | — | 0.831 |
| 2 | BS_M8M56Z4Y | pilocytic astrocytoma | — | 0.801 |
| 3 | SRR657973 | GTEX | — | 0.788 |
| 4 | MDT-AP-1164 | Med | Medulloblastoma | 0.787 |
| 5 | f693948b-2640-4fb5-b874-ec756465b5b3 | — | — | 0.781 |
| 6 | SRR5088930 | — | — | 0.772 |
| 7 | TCGA-A7-A4SA-01A-11R-A266-07 | — | A | 0.768 |
| 8 | C3L-02560 | — | cohortA1 | 0.767 |
| 9 | 82988 | EPN | Supratentorial EPN | 0.764 |
| 10 | MNG580 | — | — | 0.760 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 30 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| INTERFERON_ALPHA_RESPONSE | 0.420 | Inavolisib | — uncovered |
| NOTCH_SIGNALING | 0.400 | Inavolisib | — uncovered |
| IL6_JAK_STAT3_SIGNALING | 0.370 | Inavolisib | — uncovered |
| INTERFERON_GAMMA_RESPONSE | 0.370 | Idelalisib | — uncovered |
| BILE_ACID_METABOLISM | 0.330 | Inavolisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.270 | Remibrutinib | — uncovered |
| APICAL_SURFACE | 0.260 | Temsirolimus | — uncovered |
| ALLOGRAFT_REJECTION | 0.250 | Idelalisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.240 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.220 | Remibrutinib | — uncovered |
| FATTY_ACID_METABOLISM | 0.210 | Inavolisib | — uncovered |
| ADIPOGENESIS | 0.190 | Inavolisib | — uncovered |
| MYOGENESIS | 0.180 | Inavolisib | — uncovered |
| XENOBIOTIC_METABOLISM | 0.170 | Inavolisib | — uncovered |
| INFLAMMATORY_RESPONSE | 0.150 | Idelalisib | — uncovered |
| PEROXISOME | 0.150 | Idelalisib | — uncovered |
| IL2_STAT5_SIGNALING | 0.140 | Idelalisib | — uncovered |
| P53_PATHWAY | 0.140 | Idelalisib | — uncovered |
| REACTIVE_OXYGEN_SPECIES_PATHWAY | 0.110 | Inavolisib | — uncovered |
| UV_RESPONSE_UP | 0.110 | Idelalisib | — uncovered |