SRR650137
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- PANCREAS_BETA_CELLS+0.390
- KRAS_SIGNALING_DN+0.320
- SPERMATOGENESIS+0.120
- INTERFERON_ALPHA_RESPONSE+0.090
- P53_PATHWAY+0.030
- OXIDATIVE_PHOSPHORYLATION-0.090
- WNT_BETA_CATENIN_SIGNALING-0.140
- INTERFERON_GAMMA_RESPONSE-0.170
- MYOGENESIS-0.170
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.180
Top 10 suppressed
- PROTEIN_SECRETION-0.560
- G2M_CHECKPOINT-0.510
- ANDROGEN_RESPONSE-0.500
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.500
- E2F_TARGETS-0.490
- TGF_BETA_SIGNALING-0.490
- MITOTIC_SPINDLE-0.480
- UNFOLDED_PROTEIN_RESPONSE-0.480
- CHOLESTEROL_HOMEOSTASIS-0.470
- MTORC1_SIGNALING-0.470
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR11296796 | — | — | 0.942 |
| 2 | SRR650197 | — | — | 0.938 |
| 3 | TCGA-E7-A3Y1-01A-11R-A22U-07 | — | — | 0.927 |
| 4 | SRR8943010 | — | — | 0.925 |
| 5 | SRR4195666 | — | — | 0.922 |
| 6 | MNG599 | — | — | 0.912 |
| 7 | SRR1797231 | — | cohortSC | 0.911 |
| 8 | SRR1516050 | — | — | 0.908 |
| 9 | SRR33346946 | — | — | 0.906 |
| 10 | SRR4195693 | — | — | 0.904 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 5 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| PANCREAS_BETA_CELLS | 0.390 | Cobimetinib | — uncovered |
| KRAS_SIGNALING_DN | 0.320 | Remibrutinib | — uncovered |
| SPERMATOGENESIS | 0.120 | Inavolisib | — uncovered |
| INTERFERON_ALPHA_RESPONSE | 0.090 | Inavolisib | — uncovered |
| P53_PATHWAY | 0.030 | Idelalisib | — uncovered |