BS_94MT16N2
pilocytic astrocytoma
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- pilocytic astrocytoma
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- pilocytic astrocytoma
- age_years
- 6.359
- sex
- Male
GSVA pathway preview (0 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
2 twins match this tumor's tissue · 8 come from a different tissue of origin ← cross-tissue dominant
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | BS_21RE8W46 | pilocytic astrocytoma | — | 0.936 |
| 2 | SJEPD031_D.RNA-Seq | EPN | Posterior Fossa EPN | 0.936 |
| 3 | BS_YZ2Z1Q6Y | pilocytic astrocytoma | — | 0.920 |
| 4 | BS_J71N7D09 | Med | Medulloblastoma | 0.915 |
| 5 | SRR1421198 | GTEX | — | 0.915 |
| 6 | SJEPD014_D.RNA-Seq | EPN | Posterior Fossa EPN | 0.914 |
| 7 | BS_9F09XV62 | low-grade glioma | — | 0.910 |
| 8 | MDT-AP-0123 | Med | Medulloblastoma | 0.908 |
| 9 | MDT-AP-0208 | Med | Medulloblastoma | 0.907 |
| 10 | SRR1313642 | GTEX | — | 0.905 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 13 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| KRAS_SIGNALING_DN | 0.349 | Remibrutinib | — uncovered |
| MYOGENESIS | 0.259 | Inavolisib | — uncovered |
| BILE_ACID_METABOLISM | 0.218 | Inavolisib | — uncovered |
| APICAL_SURFACE | 0.192 | Temsirolimus | — uncovered |
| INTERFERON_ALPHA_RESPONSE | 0.143 | Inavolisib | — uncovered |
| INFLAMMATORY_RESPONSE | 0.105 | Idelalisib | — uncovered |
| ALLOGRAFT_REJECTION | 0.095 | Idelalisib | — uncovered |
| INTERFERON_GAMMA_RESPONSE | 0.089 | Idelalisib | — uncovered |
| COAGULATION | 0.062 | Binimetinib | — uncovered |
| SPERMATOGENESIS | 0.042 | Inavolisib | — uncovered |
| XENOBIOTIC_METABOLISM | 0.038 | Inavolisib | — uncovered |
| IL6_JAK_STAT3_SIGNALING | 0.032 | Inavolisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.026 | Inavolisib | — uncovered |