Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

← Cohorts · brain-umap@2

SRR934745

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876c7d61-2591-54de-ad5a-c45e45acf25b

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
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cancer_type_detailed
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subtype
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sex
Female

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • INTERFERON_ALPHA_RESPONSE+0.588
  • INTERFERON_GAMMA_RESPONSE+0.553
  • ALLOGRAFT_REJECTION+0.545
  • IL6_JAK_STAT3_SIGNALING+0.429
  • COMPLEMENT+0.403
  • INFLAMMATORY_RESPONSE+0.399
  • TGF_BETA_SIGNALING+0.355
  • NOTCH_SIGNALING+0.347
  • PROTEIN_SECRETION+0.311
  • KRAS_SIGNALING_UP+0.305

Top 10 suppressed

  • KRAS_SIGNALING_DN-0.271
  • MYOGENESIS-0.189
  • SPERMATOGENESIS-0.179
  • PANCREAS_BETA_CELLS-0.171
  • E2F_TARGETS-0.163
  • CHOLESTEROL_HOMEOSTASIS-0.162
  • ESTROGEN_RESPONSE_EARLY-0.125
  • HYPOXIA-0.097
  • XENOBIOTIC_METABOLISM-0.074
  • ESTROGEN_RESPONSE_LATE-0.069

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

7 twins match this tumor's tissue · 3 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1SRR934943
brain-umap@2
——0.893
2738B9C39-A73F-4BD5-A8D4-3F75B9E14569
brain-umap@2
——0.876
3C1CCE12B-8892-49AB-8DF2-E5E280DEAE32
brain-umap@2
——0.870
4SRR12696731
melanoma-umap@29
——0.866
5BS_9HA238XS
brain-umap@2
Neurofibroma—0.863
6BS_Z9ZS6ZS2
brain-umap@2
MPNST—0.862
7SRR934901
brain-umap@2
——0.861
8TCGA-50-5941-01A-11R-1755-07
lung-landscapes@6
—cohortA10.860
9SRR12696729
melanoma-umap@29
——0.859
10BS_49VCQD19
brain-umap@2
Neurofibroma—0.858

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 32 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
INTERFERON_ALPHA_RESPONSE0.588Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.553Idelalisib— uncovered
ALLOGRAFT_REJECTION0.545Idelalisib— uncovered
IL6_JAK_STAT3_SIGNALING0.429Inavolisib— uncovered
COMPLEMENT0.403Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.399Idelalisib— uncovered
TGF_BETA_SIGNALING0.355Inavolisib— uncovered
NOTCH_SIGNALING0.347Inavolisib— uncovered
PROTEIN_SECRETION0.311Remibrutinib— uncovered
KRAS_SIGNALING_UP0.305Inavolisib— uncovered
APOPTOSIS0.290Idelalisib— uncovered
ANGIOGENESIS0.266Remibrutinib— uncovered
IL2_STAT5_SIGNALING0.257Idelalisib— uncovered
COAGULATION0.251Binimetinib— uncovered
APICAL_SURFACE0.224Temsirolimus— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.224Inavolisib— uncovered
MITOTIC_SPINDLE0.204Inavolisib— uncovered
UV_RESPONSE_DN0.204Inavolisib— uncovered
MYC_TARGETS_V10.198Inavolisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.154Inavolisib— uncovered