SRR1420215
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Female
GSVA pathway preview (0 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1079281 | GTEX | — | 0.954 |
| 2 | SRR1340202 | GTEX | — | 0.952 |
| 3 | SRR1075433 | GTEX | — | 0.947 |
| 4 | SRR1475022 | GTEX | — | 0.937 |
| 5 | SRR1085662 | GTEX | — | 0.934 |
| 6 | SRR1415732 | GTEX | — | 0.927 |
| 7 | SRR1434138 | GTEX | — | 0.927 |
| 8 | SRR1340301 | GTEX | — | 0.925 |
| 9 | SRR612731 | GTEX | — | 0.924 |
| 10 | SRR1368222 | GTEX | — | 0.924 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 19 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| KRAS_SIGNALING_DN | 0.428 | Remibrutinib | — uncovered |
| COAGULATION | 0.297 | Binimetinib | — uncovered |
| MYOGENESIS | 0.235 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.212 | Inavolisib | — uncovered |
| EPITHELIAL_MESENCHYMAL_TRANSITION | 0.177 | Inavolisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.176 | Cobimetinib | — uncovered |
| ESTROGEN_RESPONSE_LATE | 0.158 | Idelalisib | — uncovered |
| ESTROGEN_RESPONSE_EARLY | 0.146 | Inavolisib | — uncovered |
| ANGIOGENESIS | 0.145 | Remibrutinib | — uncovered |
| HEDGEHOG_SIGNALING | 0.144 | Inavolisib | — uncovered |
| XENOBIOTIC_METABOLISM | 0.121 | Inavolisib | — uncovered |
| TNFA_SIGNALING_VIA_NFKB | 0.111 | Inavolisib | — uncovered |
| INFLAMMATORY_RESPONSE | 0.110 | Idelalisib | — uncovered |
| APICAL_JUNCTION | 0.077 | Inavolisib | — uncovered |
| APICAL_SURFACE | 0.051 | Temsirolimus | — uncovered |
| BILE_ACID_METABOLISM | 0.051 | Inavolisib | — uncovered |
| IL6_JAK_STAT3_SIGNALING | 0.043 | Inavolisib | — uncovered |
| HYPOXIA | 0.040 | Idelalisib | — uncovered |
| IL2_STAT5_SIGNALING | 0.024 | Idelalisib | — uncovered |