ERR2598237
fetal · fetal
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- fetal
- cancer_type_detailed
- —
- subtype
- fetal
- cancer_type
- fetal
- subtype
- fetal
- sex
- fetal
- race
- fetal
- fetal_age_hindbrain
- 8
- umap1_2d
- -3.872563911
- umap2_2d
- 3.032543905
- umap1_3d
- -2.168857654
- umap2_3d
- 2.763047512
- umap3_3d
- -1.514645693
- dataset
- fetal
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- HEDGEHOG_SIGNALING+0.470
- PANCREAS_BETA_CELLS+0.350
- WNT_BETA_CATENIN_SIGNALING+0.330
- NOTCH_SIGNALING+0.190
- G2M_CHECKPOINT+0.170
- DNA_REPAIR+0.150
- MITOTIC_SPINDLE+0.140
- SPERMATOGENESIS+0.130
- PEROXISOME+0.110
- MYC_TARGETS_V2+0.080
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.550
- ALLOGRAFT_REJECTION-0.460
- INTERFERON_GAMMA_RESPONSE-0.450
- IL6_JAK_STAT3_SIGNALING-0.430
- INFLAMMATORY_RESPONSE-0.410
- OXIDATIVE_PHOSPHORYLATION-0.370
- COMPLEMENT-0.360
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.340
- MYOGENESIS-0.310
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.310
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
8 twins match this tumor's tissue · 2 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | A548DB97-6D28-4DEA-8334-201093A67B1E | — | — | 0.860 |
| 2 | SRR8518307 | — | D | 0.840 |
| 3 | 2595272f-8c61-4020-b1b4-a7ff38dbc5b6 | — | — | 0.823 |
| 4 | 2e15a781-21c1-421b-9e92-6d2d414e0d14 | — | — | 0.819 |
| 5 | TCGA-34-8456-01A-21R-2326-07 | — | cohortSQ2 | 0.817 |
| 6 | TCGA-BH-A0HL-01A-11R-A10U-07 | — | B | 0.815 |
| 7 | SRR27320660 | — | — | 0.813 |
| 8 | BS_P39SQPTS | Embryonal tumors | — | 0.812 |
| 9 | TCGA-CV-A45U-01A-12R-A24H-07 | — | — | 0.806 |
| 10 | MDT-AP-0511 | Med | Medulloblastoma | 0.805 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 13 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| HEDGEHOG_SIGNALING | 0.470 | Inavolisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.350 | Cobimetinib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.330 | Inavolisib | — uncovered |
| NOTCH_SIGNALING | 0.190 | Inavolisib | — uncovered |
| G2M_CHECKPOINT | 0.170 | Inavolisib | — uncovered |
| DNA_REPAIR | 0.150 | Idelalisib | — uncovered |
| MITOTIC_SPINDLE | 0.140 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.130 | Inavolisib | — uncovered |
| PEROXISOME | 0.110 | Idelalisib | — uncovered |
| MYC_TARGETS_V2 | 0.080 | Idelalisib | — uncovered |
| E2F_TARGETS | 0.070 | Inavolisib | — uncovered |
| UV_RESPONSE_UP | 0.030 | Idelalisib | — uncovered |
| TGF_BETA_SIGNALING | 0.010 | Inavolisib | — uncovered |