Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

SRR1319539

GTEX

8d18ff56-c792-529c-b8f5-bda2de4725d7

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
GTEX
cancer_type_detailed
subtype
cancer_type
GTEX
sex
Female

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

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Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

7 twins match this tumor's tissue · 3 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1MDT-AP-2892
medullo-epn-umap@date-based
MedMedulloblastoma0.957
2MDT-AP-1215
medullo-epn-umap@date-based
MedMedulloblastoma0.954
3SRR1397906
brain-umap@2
GTEX0.952
4SRR820379
brain-umap@2
GTEX0.950
5SRR1415832
brain-umap@2
GTEX0.948
6SRR1389059
brain-umap@2
GTEX0.940
7SRR8392886
lung-landscapes@6
cohortA10.936
8sclc55A_S50.txt
lung-landscapes@6
cohortMD20.936
9BS_HHPA8NJ2
medullo-epn-umap@date-based
MedMedulloblastoma0.935
10SRR1388168
brain-umap@2
GTEX0.934

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 24 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
INFLAMMATORY_RESPONSE0.508Idelalisib— uncovered
IL6_JAK_STAT3_SIGNALING0.503Inavolisib— uncovered
ALLOGRAFT_REJECTION0.498Idelalisib— uncovered
INTERFERON_GAMMA_RESPONSE0.459Idelalisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.444Inavolisib— uncovered
PANCREAS_BETA_CELLS0.427Cobimetinib— uncovered
INTERFERON_ALPHA_RESPONSE0.425Inavolisib— uncovered
ANGIOGENESIS0.411Remibrutinib— uncovered
KRAS_SIGNALING_DN0.381Remibrutinib— uncovered
KRAS_SIGNALING_UP0.335Inavolisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.326Inavolisib— uncovered
COAGULATION0.312Binimetinib— uncovered
MYOGENESIS0.312Inavolisib— uncovered
ESTROGEN_RESPONSE_LATE0.302Idelalisib— uncovered
APICAL_SURFACE0.259Temsirolimus— uncovered
COMPLEMENT0.259Inavolisib— uncovered
IL2_STAT5_SIGNALING0.250Idelalisib— uncovered
APOPTOSIS0.238Idelalisib— uncovered
ESTROGEN_RESPONSE_EARLY0.193Inavolisib— uncovered
APICAL_JUNCTION0.165Inavolisib— uncovered