Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

ERR2598319

fetal · fetal

8ec8f307-de9a-568e-b3ed-587d6da72396

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
fetal
cancer_type_detailed
subtype
fetal
cancer_type
fetal
subtype
fetal
sex
fetal
race
fetal
fetal_age_hindbrain
20
umap1_2d
-4.960102728
umap2_2d
0.157958641
umap1_3d
0.033337408
umap2_3d
1.894958888
umap3_3d
0.413637857
dataset
fetal

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • IL6_JAK_STAT3_SIGNALING+0.620
  • INTERFERON_ALPHA_RESPONSE+0.600
  • INFLAMMATORY_RESPONSE+0.590
  • INTERFERON_GAMMA_RESPONSE+0.590
  • COAGULATION+0.520
  • EPITHELIAL_MESENCHYMAL_TRANSITION+0.520
  • ALLOGRAFT_REJECTION+0.510
  • ANGIOGENESIS+0.500
  • TNFA_SIGNALING_VIA_NFKB+0.490
  • COMPLEMENT+0.480

Top 10 suppressed

  • MYC_TARGETS_V1-0.670
  • MYC_TARGETS_V2-0.650
  • E2F_TARGETS-0.620
  • G2M_CHECKPOINT-0.600
  • DNA_REPAIR-0.450
  • MITOTIC_SPINDLE-0.440
  • UNFOLDED_PROTEIN_RESPONSE-0.390
  • PI3K_AKT_MTOR_SIGNALING-0.250
  • MTORC1_SIGNALING-0.240
  • OXIDATIVE_PHOSPHORYLATION-0.230

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

3 twins match this tumor's tissue · 7 come from a different tissue of origin ← cross-tissue dominant

#SampleCancer typeSubtypecos similarity
1MDT-AP-1254
medullo-epn-umap@date-based
MedMedulloblastoma0.956
2SRR1444622
brain-umap@2
GTEX0.948
3SRR5088905
melanoma-umap@29
0.942
4ERR2598312
medullo-epn-umap@date-based
fetalfetal0.940
5SRR1079591
brain-umap@2
GTEX0.938
6SRR1352954
brain-umap@2
GTEX0.936
7BS_3XY76V8T
brain-umap@2
Ganglioglioma0.936
8BS_KXH37MPN
brain-umap@2
DNET0.930
9SRR1431345
brain-umap@2
GTEX0.930
10sclc0617_S65.txt
lung-landscapes@6
cohortMD20.930

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 34 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
IL6_JAK_STAT3_SIGNALING0.620Inavolisib— uncovered
INTERFERON_ALPHA_RESPONSE0.600Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.590Idelalisib— uncovered
INTERFERON_GAMMA_RESPONSE0.590Idelalisib— uncovered
COAGULATION0.520Binimetinib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.520Inavolisib— uncovered
ALLOGRAFT_REJECTION0.510Idelalisib— uncovered
ANGIOGENESIS0.500Remibrutinib— uncovered
TNFA_SIGNALING_VIA_NFKB0.490Inavolisib— uncovered
COMPLEMENT0.480Inavolisib— uncovered
IL2_STAT5_SIGNALING0.420Idelalisib— uncovered
KRAS_SIGNALING_UP0.420Inavolisib— uncovered
MYOGENESIS0.410Inavolisib— uncovered
BILE_ACID_METABOLISM0.390Inavolisib— uncovered
XENOBIOTIC_METABOLISM0.390Inavolisib— uncovered
APOPTOSIS0.350Idelalisib— uncovered
HYPOXIA0.330Idelalisib— uncovered
ESTROGEN_RESPONSE_LATE0.320Idelalisib— uncovered
PANCREAS_BETA_CELLS0.320Cobimetinib— uncovered
ESTROGEN_RESPONSE_EARLY0.310Inavolisib— uncovered