266352
EPN · EPN Tumor
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- EPN
- cancer_type_detailed
- —
- subtype
- EPN Tumor
- cancer_type
- EPN
- subtype
- EPN Tumor
- age_years
- 5
- fusion
- ZFTA_RELA
- e1_e2
- E1
- umap1_2d
- -3.41748939
- umap2_2d
- 3.202998551
- umap1_3d
- -1.471347084
- umap2_3d
- 2.885772168
- umap3_3d
- -1.510681573
- dataset
- EPN-Felix
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- G2M_CHECKPOINT+0.370
- SPERMATOGENESIS+0.370
- E2F_TARGETS+0.360
- PANCREAS_BETA_CELLS+0.340
- KRAS_SIGNALING_DN+0.220
- MYC_TARGETS_V1+0.180
- MITOTIC_SPINDLE+0.140
- COAGULATION+0.050
- MYOGENESIS+0.000
- WNT_BETA_CATENIN_SIGNALING+0.000
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.600
- INTERFERON_GAMMA_RESPONSE-0.540
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.490
- IL6_JAK_STAT3_SIGNALING-0.410
- TNFA_SIGNALING_VIA_NFKB-0.400
- P53_PATHWAY-0.390
- ADIPOGENESIS-0.380
- INFLAMMATORY_RESPONSE-0.360
- OXIDATIVE_PHOSPHORYLATION-0.360
- ALLOGRAFT_REJECTION-0.350
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
2 twins match this tumor's tissue · 8 come from a different tissue of origin ← cross-tissue dominant
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | BS_HHPA8NJ2 | medulloblastoma | — | 0.945 |
| 2 | BS_VVFBW0YH | medulloblastoma | — | 0.923 |
| 3 | MNG459 | — | — | 0.912 |
| 4 | BS_S1M423AB | Embryonal tumors | — | 0.912 |
| 5 | BS_W311713R | medulloblastoma | — | 0.911 |
| 6 | BS_JT82QGXF | medulloblastoma | — | 0.911 |
| 7 | C3L-02616 | — | cohortMD1 | 0.908 |
| 8 | BS_JVW2JJ39 | high-grade glioma | — | 0.905 |
| 9 | BS_44A3ES23 | medulloblastoma | — | 0.904 |
| 10 | BS_1TWCV047 | Embryonal tumors | — | 0.904 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 8 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| G2M_CHECKPOINT | 0.370 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.370 | Inavolisib | — uncovered |
| E2F_TARGETS | 0.360 | Inavolisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.340 | Cobimetinib | — uncovered |
| KRAS_SIGNALING_DN | 0.220 | Remibrutinib | — uncovered |
| MYC_TARGETS_V1 | 0.180 | Inavolisib | — uncovered |
| MITOTIC_SPINDLE | 0.140 | Inavolisib | — uncovered |
| COAGULATION | 0.050 | Binimetinib | — uncovered |