SRR650147
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- E2F_TARGETS+0.620
- G2M_CHECKPOINT+0.470
- SPERMATOGENESIS+0.250
- MITOTIC_SPINDLE+0.240
- DNA_REPAIR+0.120
- PEROXISOME+0.090
- FATTY_ACID_METABOLISM+0.050
- KRAS_SIGNALING_DN+0.050
- CHOLESTEROL_HOMEOSTASIS-0.010
- PANCREAS_BETA_CELLS-0.020
Top 10 suppressed
- ALLOGRAFT_REJECTION-0.520
- INTERFERON_GAMMA_RESPONSE-0.460
- INFLAMMATORY_RESPONSE-0.420
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.390
- ANDROGEN_RESPONSE-0.370
- INTERFERON_ALPHA_RESPONSE-0.370
- COMPLEMENT-0.360
- HYPOXIA-0.350
- IL2_STAT5_SIGNALING-0.350
- P53_PATHWAY-0.350
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
7 twins match this tumor's tissue · 3 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR12202476 | — | — | 0.921 |
| 2 | TCGA-GU-A42P-01A-11R-A23W-07 | — | — | 0.894 |
| 3 | SRR8943043 | — | — | 0.893 |
| 4 | c01b5135.b754.4c57.a81d.68a951803fab | — | cohortMD1 | 0.889 |
| 5 | SRR8518343 | — | E | 0.886 |
| 6 | SRR23303756 | — | — | 0.883 |
| 7 | BS_3NWQXPQV | medulloblastoma | — | 0.882 |
| 8 | BS_W311713R | medulloblastoma | — | 0.876 |
| 9 | TCGA-KQ-A41Q-01A-11R-A33J-07 | — | — | 0.875 |
| 10 | BS_KN92S7YQ | medulloblastoma | — | 0.875 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 8 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| E2F_TARGETS | 0.620 | Inavolisib | — uncovered |
| G2M_CHECKPOINT | 0.470 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.250 | Inavolisib | — uncovered |
| MITOTIC_SPINDLE | 0.240 | Inavolisib | — uncovered |
| DNA_REPAIR | 0.120 | Idelalisib | — uncovered |
| PEROXISOME | 0.090 | Idelalisib | — uncovered |
| FATTY_ACID_METABOLISM | 0.050 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.050 | Remibrutinib | — uncovered |