Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

BS_769BDPDB

pilocytic astrocytoma

8fa21eab-0cd2-5faf-846a-7b7dadb39860

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
pilocytic astrocytoma
cancer_type_detailed
subtype
cancer_type
pilocytic astrocytoma
overall_survival_months
251.14980289093296
age_years
4.186
sex
Male

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

2 twins match this tumor's tissue · 8 come from a different tissue of origin ← cross-tissue dominant

#SampleCancer typeSubtypecos similarity
1BS_E4GC9EXR
brain-umap@2
Ganglioglioma0.972
2s_150203_1a
medullo-epn-umap@date-based
EPNPosterior Fossa EPN0.969
3BS_D3YBV7KB
brain-umap@2
low-grade glioma0.967
4BS_55JW3HFM
brain-umap@2
Ganglioglioma0.958
5BS_JH29M4KG
brain-umap@2
pilocytic astrocytoma0.951
6SRR1455369
brain-umap@2
GTEX0.951
7SJEPD009_D.RNA-Seq
medullo-epn-umap@date-based
EPNPosterior Fossa EPN0.951
8BS_8VAZSJEN
brain-umap@2
pilocytic astrocytoma0.951
9BS_24AHZ9ZW
brain-umap@2
low-grade glioma0.950
10BS_W7FP2G3F
brain-umap@2
DNET0.949

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 40 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
IL6_JAK_STAT3_SIGNALING0.683Inavolisib— uncovered
INTERFERON_ALPHA_RESPONSE0.675Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.669Idelalisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.657Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.641Idelalisib— uncovered
ALLOGRAFT_REJECTION0.635Idelalisib— uncovered
COAGULATION0.548Binimetinib— uncovered
COMPLEMENT0.519Inavolisib— uncovered
IL2_STAT5_SIGNALING0.513Idelalisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.501Inavolisib— uncovered
ANGIOGENESIS0.491Remibrutinib— uncovered
P53_PATHWAY0.451Idelalisib— uncovered
KRAS_SIGNALING_UP0.446Inavolisib— uncovered
APOPTOSIS0.442Idelalisib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.432Inavolisib— uncovered
HYPOXIA0.419Idelalisib— uncovered
MYOGENESIS0.372Inavolisib— uncovered
ESTROGEN_RESPONSE_EARLY0.364Inavolisib— uncovered
APICAL_SURFACE0.357Temsirolimus— uncovered
XENOBIOTIC_METABOLISM0.339Inavolisib— uncovered