Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-BH-A1EO-01A-11R-A137-07

· A

910bf3f1-a033-5e57-8d58-926f4b8ec6e7

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
A
subtype
A
overall_survival_months
93

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1TCGA-46-3767-01A-01R-0980-07
lung-landscapes@6
cohortSQ10.919
2TCGA-A2-A0T6-01A-11R-A084-07
breast-umap@18
A0.909
3TCGA-AR-A24O-01A-11R-A169-07
breast-umap@18
A0.901
4TCGA-44-6774-01A-21R-1858-07
lung-landscapes@6
cohortA10.894
5SRR35579817
breast-umap@18
A0.888
6TCGA-60-2704-01A-11R-2045-07
lung-landscapes@6
cohortSQ10.887
7TCGA-E9-A1NG-01A-21R-A14M-07
breast-umap@18
A0.887
8fd618c1b-e230-408d-aed8-4ad6df3fc4e6
colon-landscapes@1
0.886
969842b4c-448a-4275-8250-7b31948c56ec
colon-landscapes@1
0.883
10SRR6013569
lung-landscapes@6
cohortMD20.881

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 27 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
EPITHELIAL_MESENCHYMAL_TRANSITION0.570Inavolisib— uncovered
TGF_BETA_SIGNALING0.500Inavolisib— uncovered
UV_RESPONSE_DN0.460Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.390Idelalisib— uncovered
PROTEIN_SECRETION0.390Remibrutinib— uncovered
ANGIOGENESIS0.380Remibrutinib— uncovered
KRAS_SIGNALING_UP0.370Inavolisib— uncovered
COMPLEMENT0.320Inavolisib— uncovered
ALLOGRAFT_REJECTION0.300Idelalisib— uncovered
COAGULATION0.280Binimetinib— uncovered
IL6_JAK_STAT3_SIGNALING0.280Inavolisib— uncovered
HEDGEHOG_SIGNALING0.270Inavolisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.250Inavolisib— uncovered
APICAL_JUNCTION0.240Inavolisib— uncovered
ANDROGEN_RESPONSE0.220Inavolisib— uncovered
IL2_STAT5_SIGNALING0.200Idelalisib— uncovered
NOTCH_SIGNALING0.190Inavolisib— uncovered
APOPTOSIS0.170Idelalisib— uncovered
HEME_METABOLISM0.150Temsirolimus— uncovered
APICAL_SURFACE0.120Temsirolimus— uncovered