Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

← Cohorts · lung-landscapes@6

SRR6013502

— · cohortA1

918e85cb-9889-56a8-851d-0e1c17630a53

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
—
cancer_type_detailed
—
subtype
cohortA1
subtype
cohortA1

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • INTERFERON_ALPHA_RESPONSE+0.580
  • PROTEIN_SECRETION+0.440
  • INTERFERON_GAMMA_RESPONSE+0.390
  • OXIDATIVE_PHOSPHORYLATION+0.330
  • CHOLESTEROL_HOMEOSTASIS+0.300
  • PEROXISOME+0.280
  • ADIPOGENESIS+0.270
  • HEME_METABOLISM+0.200
  • REACTIVE_OXYGEN_SPECIES_PATHWAY+0.170
  • FATTY_ACID_METABOLISM+0.140

Top 10 suppressed

  • G2M_CHECKPOINT-0.400
  • ANGIOGENESIS-0.330
  • EPITHELIAL_MESENCHYMAL_TRANSITION-0.330
  • HYPOXIA-0.320
  • MYC_TARGETS_V2-0.320
  • E2F_TARGETS-0.290
  • PANCREAS_BETA_CELLS-0.180
  • MYC_TARGETS_V1-0.170
  • TNFA_SIGNALING_VIA_NFKB-0.160
  • MITOTIC_SPINDLE-0.120

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

6 twins match this tumor's tissue · 4 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1131536
medullo-epn-umap@date-based
EPNEPN Tumor0.826
2X44dc4429.1bfa.4845.b2ed.028feafe7d4a
lung-landscapes@6
—cohortA10.803
3BS_N210XMKR
brain-umap@2
low-grade glioma—0.763
4C3L-02549
lung-landscapes@6
—cohortA10.763
5BS_AG3D3435
brain-umap@2
subependymal giant cell astrocytoma(SEGA)—0.754
6R149
bladder-landscape@3
——0.752
7BS_H3FE3TH9
brain-umap@2
pilocytic astrocytoma—0.745
8dcabd821.c5d5.4a97.b657.0612d6a4439d
lung-landscapes@6
—cohortA10.743
9TCGA-78-7539-01A-11R-2066-07
lung-landscapes@6
—cohortA10.738
10SRR8942958
bladder-landscape@3
——0.737

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 26 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
INTERFERON_ALPHA_RESPONSE0.580Inavolisib— uncovered
PROTEIN_SECRETION0.440Remibrutinib— uncovered
INTERFERON_GAMMA_RESPONSE0.390Idelalisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.330Remibrutinib— uncovered
CHOLESTEROL_HOMEOSTASIS0.300Remibrutinib— uncovered
PEROXISOME0.280Idelalisib— uncovered
ADIPOGENESIS0.270Inavolisib— uncovered
HEME_METABOLISM0.200Temsirolimus— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.170Inavolisib— uncovered
FATTY_ACID_METABOLISM0.140Inavolisib— uncovered
DNA_REPAIR0.120Idelalisib— uncovered
ALLOGRAFT_REJECTION0.110Idelalisib— uncovered
ANDROGEN_RESPONSE0.100Inavolisib— uncovered
TGF_BETA_SIGNALING0.100Inavolisib— uncovered
UV_RESPONSE_UP0.100Idelalisib— uncovered
APICAL_JUNCTION0.090Inavolisib— uncovered
IL2_STAT5_SIGNALING0.080Idelalisib— uncovered
BILE_ACID_METABOLISM0.070Inavolisib— uncovered
PI3K_AKT_MTOR_SIGNALING0.070Inavolisib— uncovered
XENOBIOTIC_METABOLISM0.070Inavolisib— uncovered