SRR6013539
— · cohortMD2
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- cohortMD2
- subtype
- cohortMD2
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- TNFA_SIGNALING_VIA_NFKB+0.650
- MYOGENESIS+0.510
- INFLAMMATORY_RESPONSE+0.500
- HEDGEHOG_SIGNALING+0.430
- IL6_JAK_STAT3_SIGNALING+0.430
- EPITHELIAL_MESENCHYMAL_TRANSITION+0.410
- TGF_BETA_SIGNALING+0.410
- UV_RESPONSE_DN+0.400
- APICAL_JUNCTION+0.360
- IL2_STAT5_SIGNALING+0.320
Top 10 suppressed
- E2F_TARGETS-0.660
- OXIDATIVE_PHOSPHORYLATION-0.600
- MYC_TARGETS_V1-0.570
- G2M_CHECKPOINT-0.540
- DNA_REPAIR-0.470
- GLYCOLYSIS-0.470
- PROTEIN_SECRETION-0.460
- UNFOLDED_PROTEIN_RESPONSE-0.430
- MTORC1_SIGNALING-0.400
- MYC_TARGETS_V2-0.380
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
9 twins match this tumor's tissue · 1 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | TCGA-4Z-AA7N-01A-11R-A39I-07 | — | — | 0.956 |
| 2 | TCGA-98-A53D-01A-32R-A262-07 | — | cohortMD2 | 0.948 |
| 3 | TCGA-OL-A6VQ-01A-12R-A41B-07 | — | A | 0.936 |
| 4 | MNG130 | — | — | 0.927 |
| 5 | SRR1498861 | GTEX | — | 0.924 |
| 6 | TCGA-AC-A23G-01A-11R-A213-07 | — | A | 0.917 |
| 7 | TCGA-56-A4ZJ-01A-11R-A262-07 | — | cohortSQ1 | 0.916 |
| 8 | TCGA-38-7271-01A-11R-2039-07 | — | cohortMD2 | 0.914 |
| 9 | C3N-02237 | — | cohortA1 | 0.914 |
| 10 | TCGA-75-7030-01A-11R-1949-07 | — | cohortA1 | 0.913 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 31 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| TNFA_SIGNALING_VIA_NFKB | 0.650 | Inavolisib | — uncovered |
| MYOGENESIS | 0.510 | Inavolisib | — uncovered |
| INFLAMMATORY_RESPONSE | 0.500 | Idelalisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.430 | Inavolisib | — uncovered |
| IL6_JAK_STAT3_SIGNALING | 0.430 | Inavolisib | — uncovered |
| EPITHELIAL_MESENCHYMAL_TRANSITION | 0.410 | Inavolisib | — uncovered |
| TGF_BETA_SIGNALING | 0.410 | Inavolisib | — uncovered |
| UV_RESPONSE_DN | 0.400 | Inavolisib | — uncovered |
| APICAL_JUNCTION | 0.360 | Inavolisib | — uncovered |
| IL2_STAT5_SIGNALING | 0.320 | Idelalisib | — uncovered |
| KRAS_SIGNALING_UP | 0.320 | Inavolisib | — uncovered |
| ANGIOGENESIS | 0.310 | Remibrutinib | — uncovered |
| KRAS_SIGNALING_DN | 0.310 | Remibrutinib | — uncovered |
| COAGULATION | 0.300 | Binimetinib | — uncovered |
| APICAL_SURFACE | 0.290 | Temsirolimus | — uncovered |
| COMPLEMENT | 0.290 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_EARLY | 0.280 | Inavolisib | — uncovered |
| HYPOXIA | 0.260 | Idelalisib | — uncovered |
| APOPTOSIS | 0.250 | Idelalisib | — uncovered |
| ALLOGRAFT_REJECTION | 0.240 | Idelalisib | — uncovered |