Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

SRR1516056

9327fada-702a-5af5-a8db-03a8b5dc5c8e

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
sex
Female

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1SRR1516055
bladder-landscape@3
0.978
2TCGA-XF-A9SY-01A-21R-A42T-07
bladder-landscape@3
0.946
3fca4c327-dfab-4455-84a8-f890a7326132
colon-landscapes@1
0.930
4TCGA-XF-A9SM-01A-11R-A42T-07
bladder-landscape@3
0.928
5R209
bladder-landscape@3
0.928
6TCGA-ZF-AA58-01A-12R-A42T-07
bladder-landscape@3
0.921
7SRR29022839
breast-umap@18
A0.915
8s0112234
melanoma-umap@29
0.904
9TCGA-FD-A3B3-01A-12R-A206-07
bladder-landscape@3
0.899
106e639239-cdae-4412-880f-ef813a956ff7
colon-landscapes@1
0.899

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 38 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
INTERFERON_ALPHA_RESPONSE0.710Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.610Idelalisib— uncovered
ALLOGRAFT_REJECTION0.600Idelalisib— uncovered
E2F_TARGETS0.560Inavolisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.530Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.530Idelalisib— uncovered
G2M_CHECKPOINT0.490Inavolisib— uncovered
IL6_JAK_STAT3_SIGNALING0.480Inavolisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.460Inavolisib— uncovered
MYC_TARGETS_V20.450Idelalisib— uncovered
ANGIOGENESIS0.400Remibrutinib— uncovered
COMPLEMENT0.400Inavolisib— uncovered
MYC_TARGETS_V10.400Inavolisib— uncovered
MTORC1_SIGNALING0.390Inavolisib— uncovered
DNA_REPAIR0.370Idelalisib— uncovered
MITOTIC_SPINDLE0.360Inavolisib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.360Idelalisib— uncovered
IL2_STAT5_SIGNALING0.350Idelalisib— uncovered
APOPTOSIS0.310Idelalisib— uncovered
UV_RESPONSE_UP0.310Idelalisib— uncovered