Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

← Cohorts · mng-umap@100

MNG11

—

9508e487-f87e-5377-9f64-2f6c6bc89329

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
—
cancer_type_detailed
—
subtype
—

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • ESTROGEN_RESPONSE_EARLY+0.360
  • PANCREAS_BETA_CELLS+0.305
  • ESTROGEN_RESPONSE_LATE+0.277
  • HYPOXIA+0.266
  • ANDROGEN_RESPONSE+0.263
  • TGF_BETA_SIGNALING+0.231
  • EPITHELIAL_MESENCHYMAL_TRANSITION+0.229
  • UV_RESPONSE_DN+0.208
  • ANGIOGENESIS+0.196
  • APICAL_SURFACE+0.186

Top 10 suppressed

  • MYC_TARGETS_V2-0.469
  • OXIDATIVE_PHOSPHORYLATION-0.464
  • WNT_BETA_CATENIN_SIGNALING-0.430
  • DNA_REPAIR-0.413
  • INTERFERON_ALPHA_RESPONSE-0.376
  • MYC_TARGETS_V1-0.349
  • E2F_TARGETS-0.333
  • MITOTIC_SPINDLE-0.277
  • ALLOGRAFT_REJECTION-0.267
  • PI3K_AKT_MTOR_SIGNALING-0.232

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

9 twins match this tumor's tissue · 1 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1MNG330
mng-umap@100
——0.860
2MNG121
mng-umap@100
——0.841
3MNG931
mng-umap@100
——0.821
4MNG359
mng-umap@100
——0.817
5MNG326
mng-umap@100
——0.811
6MNG325
mng-umap@100
——0.803
7MNG113
mng-umap@100
——0.801
8MNG806
mng-umap@100
——0.799
9SRR614539
brain-umap@2
GTEX—0.796
10MNG417
mng-umap@100
——0.796

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 24 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
ESTROGEN_RESPONSE_EARLY0.360Inavolisib— uncovered
PANCREAS_BETA_CELLS0.305Cobimetinib— uncovered
ESTROGEN_RESPONSE_LATE0.277Idelalisib— uncovered
HYPOXIA0.266Idelalisib— uncovered
ANDROGEN_RESPONSE0.263Inavolisib— uncovered
TGF_BETA_SIGNALING0.231Inavolisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.229Inavolisib— uncovered
UV_RESPONSE_DN0.208Inavolisib— uncovered
ANGIOGENESIS0.196Remibrutinib— uncovered
APICAL_SURFACE0.186Temsirolimus— uncovered
KRAS_SIGNALING_DN0.178Remibrutinib— uncovered
SPERMATOGENESIS0.166Inavolisib— uncovered
COAGULATION0.165Binimetinib— uncovered
BILE_ACID_METABOLISM0.159Inavolisib— uncovered
HEDGEHOG_SIGNALING0.155Inavolisib— uncovered
XENOBIOTIC_METABOLISM0.145Inavolisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.137Inavolisib— uncovered
MYOGENESIS0.115Inavolisib— uncovered
KRAS_SIGNALING_UP0.105Inavolisib— uncovered
MTORC1_SIGNALING0.080Inavolisib— uncovered