Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

9075936e-cc58-4740-abf4-1c733abb3d9f

9b616323-41bb-57d7-8ed8-bbce0f38cd9c

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

7 twins match this tumor's tissue · 3 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1TCGA-E9-A5FK-01A-11R-A27Q-07
breast-umap@18
B0.945
223849071-df2e-4421-b91d-90f66ec2c162
melanoma-umap@29
0.926
3SRR1339968
brain-umap@2
GTEX0.924
4TCGA-A2-A0CR-01A-11R-A22K-07
breast-umap@18
B0.921
5TCGA-FD-A43S-01A-21R-A23W-07
bladder-landscape@3
0.920
6SRR1491293
brain-umap@2
GTEX0.916
7TCGA-AC-A3BB-01A-21R-A19W-07
breast-umap@18
A0.914
837870efb-e4e9-4772-bdec-b9de38ce4aec
melanoma-umap@29
0.914
9TCGA-BH-A5J0-01A-11R-A27Q-07
breast-umap@18
B0.911
10SRR1442666
brain-umap@2
GTEX0.908

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 25 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
COAGULATION0.500Binimetinib— uncovered
INTERFERON_ALPHA_RESPONSE0.500Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.500Idelalisib— uncovered
ALLOGRAFT_REJECTION0.400Idelalisib— uncovered
ANGIOGENESIS0.400Remibrutinib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.400Inavolisib— uncovered
IL6_JAK_STAT3_SIGNALING0.400Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.400Idelalisib— uncovered
KRAS_SIGNALING_DN0.400Remibrutinib— uncovered
PANCREAS_BETA_CELLS0.400Cobimetinib— uncovered
APICAL_JUNCTION0.300Inavolisib— uncovered
COMPLEMENT0.300Inavolisib— uncovered
ESTROGEN_RESPONSE_LATE0.300Idelalisib— uncovered
IL2_STAT5_SIGNALING0.300Idelalisib— uncovered
KRAS_SIGNALING_UP0.300Inavolisib— uncovered
MYOGENESIS0.300Inavolisib— uncovered
P53_PATHWAY0.300Idelalisib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.300Inavolisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.300Inavolisib— uncovered
XENOBIOTIC_METABOLISM0.300Inavolisib— uncovered