8b88f1a0-d67d-4400-95c1-dc00ceb8b15f
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Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
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- cancer_type_detailed
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- subtype
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GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- INTERFERON_ALPHA_RESPONSE+0.600
- E2F_TARGETS+0.500
- G2M_CHECKPOINT+0.500
- MITOTIC_SPINDLE+0.500
- INTERFERON_GAMMA_RESPONSE+0.400
- MTORC1_SIGNALING+0.400
- PI3K_AKT_MTOR_SIGNALING+0.300
- PROTEIN_SECRETION+0.300
- UNFOLDED_PROTEIN_RESPONSE+0.300
- ALLOGRAFT_REJECTION+0.200
Top 10 suppressed
- KRAS_SIGNALING_DN-0.300
- MYOGENESIS-0.300
- APICAL_JUNCTION-0.200
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.200
- NOTCH_SIGNALING-0.200
- ANGIOGENESIS-0.100
- APICAL_SURFACE-0.100
- COAGULATION-0.100
- KRAS_SIGNALING_UP-0.100
- PANCREAS_BETA_CELLS-0.100
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
9 twins match this tumor's tissue · 1 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | 4c67fdfb-4b74-46c4-9021-0b5317207db5 | — | — | 0.835 |
| 2 | TCGA-XF-AAN2-01A-11R-A42T-07 | — | — | 0.833 |
| 3 | R427 | — | — | 0.822 |
| 4 | BS_D7XRFE0R | Diffuse intrinsic pontine glioma | — | 0.812 |
| 5 | d5610bbc-93c5-4ca5-b687-f955d1b84c92 | — | — | 0.803 |
| 6 | TCGA-AR-A0TQ-01A-11R-A084-07 | — | B | 0.789 |
| 7 | R371 | — | — | 0.787 |
| 8 | MNG533 | — | — | 0.785 |
| 9 | sclc239861_S78.txt | — | cohortSC | 0.779 |
| 10 | E0173AAB-678A-46E0-B701-C79A6BE9B9D8 | — | — | 0.778 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 30 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| INTERFERON_ALPHA_RESPONSE | 0.600 | Inavolisib | — uncovered |
| E2F_TARGETS | 0.500 | Inavolisib | — uncovered |
| G2M_CHECKPOINT | 0.500 | Inavolisib | — uncovered |
| MITOTIC_SPINDLE | 0.500 | Inavolisib | — uncovered |
| INTERFERON_GAMMA_RESPONSE | 0.400 | Idelalisib | — uncovered |
| MTORC1_SIGNALING | 0.400 | Inavolisib | — uncovered |
| PI3K_AKT_MTOR_SIGNALING | 0.300 | Inavolisib | — uncovered |
| PROTEIN_SECRETION | 0.300 | Remibrutinib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.300 | Idelalisib | — uncovered |
| ALLOGRAFT_REJECTION | 0.200 | Idelalisib | — uncovered |
| APOPTOSIS | 0.200 | Idelalisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.200 | Inavolisib | — uncovered |
| HEME_METABOLISM | 0.200 | Temsirolimus | — uncovered |
| IL6_JAK_STAT3_SIGNALING | 0.200 | Inavolisib | — uncovered |
| REACTIVE_OXYGEN_SPECIES_PATHWAY | 0.200 | Inavolisib | — uncovered |
| ADIPOGENESIS | 0.100 | Inavolisib | — uncovered |
| ANDROGEN_RESPONSE | 0.100 | Inavolisib | — uncovered |
| BILE_ACID_METABOLISM | 0.100 | Inavolisib | — uncovered |
| DNA_REPAIR | 0.100 | Idelalisib | — uncovered |
| FATTY_ACID_METABOLISM | 0.100 | Inavolisib | — uncovered |