Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

← Cohorts · mng-umap@100

MNG1206

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9ddc608d-f8d3-508d-86d5-d8b69ebac2b4

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
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cancer_type_detailed
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subtype
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GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • PROTEIN_SECRETION+0.502
  • TGF_BETA_SIGNALING+0.473
  • MYC_TARGETS_V1+0.450
  • DNA_REPAIR+0.420
  • ADIPOGENESIS+0.395
  • OXIDATIVE_PHOSPHORYLATION+0.369
  • UV_RESPONSE_DN+0.367
  • UNFOLDED_PROTEIN_RESPONSE+0.335
  • ANDROGEN_RESPONSE+0.334
  • PI3K_AKT_MTOR_SIGNALING+0.315

Top 10 suppressed

  • ANGIOGENESIS-0.311
  • KRAS_SIGNALING_DN-0.279
  • INFLAMMATORY_RESPONSE-0.192
  • ALLOGRAFT_REJECTION-0.172
  • HEDGEHOG_SIGNALING-0.139
  • PANCREAS_BETA_CELLS-0.126
  • TNFA_SIGNALING_VIA_NFKB-0.118
  • COAGULATION-0.074
  • IL6_JAK_STAT3_SIGNALING-0.072
  • COMPLEMENT-0.067

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

9 twins match this tumor's tissue · 1 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1SJEPD031129_D1.RNA-Seq
medullo-epn-umap@date-based
EPNPosterior Fossa EPN0.840
2MNG328
mng-umap@100
——0.839
3BE6A3670-34C4-4FD3-9794-C5B3254D9224
brain-umap@2
——0.833
4MNG925
mng-umap@100
——0.827
510EE3CFC-9230-40BA-9C9F-77949BA763CC
brain-umap@2
——0.818
6MNG1038
mng-umap@100
——0.810
70A7A28BA-9D46-4D4F-A0A5-B3F9AA8DF29B
brain-umap@2
——0.806
815824B66-5519-459A-B0C2-6EABAEEC2D8A
brain-umap@2
——0.801
93C612089-3AF3-4999-9F46-3EF083AFF90D
brain-umap@2
——0.800
10C4A69C6F-E199-43CF-9DA1-94E1B3AE7388
brain-umap@2
——0.794

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 32 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
PROTEIN_SECRETION0.502Remibrutinib— uncovered
TGF_BETA_SIGNALING0.473Inavolisib— uncovered
MYC_TARGETS_V10.450Inavolisib— uncovered
DNA_REPAIR0.420Idelalisib— uncovered
ADIPOGENESIS0.395Inavolisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.369Remibrutinib— uncovered
UV_RESPONSE_DN0.367Inavolisib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.335Idelalisib— uncovered
ANDROGEN_RESPONSE0.334Inavolisib— uncovered
PI3K_AKT_MTOR_SIGNALING0.315Inavolisib— uncovered
MITOTIC_SPINDLE0.311Inavolisib— uncovered
HEME_METABOLISM0.295Temsirolimus— uncovered
MTORC1_SIGNALING0.285Inavolisib— uncovered
FATTY_ACID_METABOLISM0.274Inavolisib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.262Inavolisib— uncovered
UV_RESPONSE_UP0.261Idelalisib— uncovered
PEROXISOME0.232Idelalisib— uncovered
APOPTOSIS0.228Idelalisib— uncovered
CHOLESTEROL_HOMEOSTASIS0.202Remibrutinib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.202Inavolisib— uncovered