86db93b2-14b0-4094-bd69-222582df130c
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Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
- age_years
- 80
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- UV_RESPONSE_DN+0.400
- INFLAMMATORY_RESPONSE+0.340
- TGF_BETA_SIGNALING+0.330
- TNFA_SIGNALING_VIA_NFKB+0.320
- HEDGEHOG_SIGNALING+0.300
- IL6_JAK_STAT3_SIGNALING+0.290
- INTERFERON_GAMMA_RESPONSE+0.280
- ALLOGRAFT_REJECTION+0.270
- KRAS_SIGNALING_UP+0.270
- EPITHELIAL_MESENCHYMAL_TRANSITION+0.250
Top 10 suppressed
- MYC_TARGETS_V2-0.630
- OXIDATIVE_PHOSPHORYLATION-0.630
- MYC_TARGETS_V1-0.600
- DNA_REPAIR-0.480
- ADIPOGENESIS-0.410
- MTORC1_SIGNALING-0.400
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.400
- E2F_TARGETS-0.380
- FATTY_ACID_METABOLISM-0.380
- UNFOLDED_PROTEIN_RESPONSE-0.370
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | 023160e4-1d9a-499c-9bfa-1b3aacf284f2 | — | — | 0.941 |
| 2 | SRR4195664 | — | — | 0.927 |
| 3 | TCGA-A7-A26F-01B-04R-A22O-07 | — | D | 0.918 |
| 4 | a307b24f-4caa-403a-8313-2a4604f2079a | — | — | 0.914 |
| 5 | AUR-AE6X-TTP1-A-1-0-R-A741-41 | — | D | 0.913 |
| 6 | AUR-AG12-TTP1-A-1-0-R-A741-41 | — | A | 0.904 |
| 7 | ad478846-0a75-4081-ac09-37ee5415d9b4 | — | — | 0.900 |
| 8 | ec48e2b8-ca0a-40fe-a87b-f0e955466840 | — | — | 0.893 |
| 9 | TCGA-55-7574-01A-11R-2039-07 | — | cohortMD2 | 0.890 |
| 10 | C3N-03233 | — | cohortA1 | 0.888 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 22 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| UV_RESPONSE_DN | 0.400 | Inavolisib | — uncovered |
| INFLAMMATORY_RESPONSE | 0.340 | Idelalisib | — uncovered |
| TGF_BETA_SIGNALING | 0.330 | Inavolisib | — uncovered |
| TNFA_SIGNALING_VIA_NFKB | 0.320 | Inavolisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.300 | Inavolisib | — uncovered |
| IL6_JAK_STAT3_SIGNALING | 0.290 | Inavolisib | — uncovered |
| INTERFERON_GAMMA_RESPONSE | 0.280 | Idelalisib | — uncovered |
| ALLOGRAFT_REJECTION | 0.270 | Idelalisib | — uncovered |
| KRAS_SIGNALING_UP | 0.270 | Inavolisib | — uncovered |
| EPITHELIAL_MESENCHYMAL_TRANSITION | 0.250 | Inavolisib | — uncovered |
| APICAL_SURFACE | 0.240 | Temsirolimus | — uncovered |
| KRAS_SIGNALING_DN | 0.220 | Remibrutinib | — uncovered |
| COMPLEMENT | 0.200 | Inavolisib | — uncovered |
| MITOTIC_SPINDLE | 0.190 | Inavolisib | — uncovered |
| IL2_STAT5_SIGNALING | 0.170 | Idelalisib | — uncovered |
| ANGIOGENESIS | 0.120 | Remibrutinib | — uncovered |
| NOTCH_SIGNALING | 0.120 | Inavolisib | — uncovered |
| ANDROGEN_RESPONSE | 0.090 | Inavolisib | — uncovered |
| INTERFERON_ALPHA_RESPONSE | 0.090 | Inavolisib | — uncovered |
| APICAL_JUNCTION | 0.070 | Inavolisib | — uncovered |