Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-C8-A26Z-01A-11R-A16F-07

· B

9ef3a4bc-0af9-55e4-801d-872c2ba6f389

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
B
subtype
B
overall_survival_months
16

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • PROTEIN_SECRETION+0.450
  • ESTROGEN_RESPONSE_EARLY+0.260
  • DNA_REPAIR+0.230
  • PANCREAS_BETA_CELLS+0.190
  • PEROXISOME+0.190
  • OXIDATIVE_PHOSPHORYLATION+0.150
  • UNFOLDED_PROTEIN_RESPONSE+0.150
  • MITOTIC_SPINDLE+0.140
  • ESTROGEN_RESPONSE_LATE+0.130
  • MYC_TARGETS_V1+0.130

Top 10 suppressed

  • ALLOGRAFT_REJECTION-0.580
  • INTERFERON_ALPHA_RESPONSE-0.560
  • IL6_JAK_STAT3_SIGNALING-0.510
  • INTERFERON_GAMMA_RESPONSE-0.510
  • INFLAMMATORY_RESPONSE-0.480
  • TNFA_SIGNALING_VIA_NFKB-0.390
  • KRAS_SIGNALING_UP-0.360
  • COMPLEMENT-0.320
  • EPITHELIAL_MESENCHYMAL_TRANSITION-0.250
  • KRAS_SIGNALING_DN-0.240

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1TCGA-E2-A1IE-01A-11R-A13Q-07
breast-umap@18
B0.902
2TCGA-E2-A156-01A-11R-A12D-07
breast-umap@18
B0.885
3TCGA-E2-A15T-01A-11R-A115-07
breast-umap@18
B0.850
4TCGA-E9-A1R7-01A-11R-A14M-07
breast-umap@18
B0.848
5TCGA-D8-A1XR-01A-11R-A14M-07
breast-umap@18
B0.845
6TCGA-EW-A1OX-01A-11R-A144-07
breast-umap@18
B0.837
7TCGA-E9-A1RC-01A-11R-A157-07
breast-umap@18
B0.833
8TCGA-BH-A0E7-01A-11R-A034-07
breast-umap@18
B0.833
9sclc2008_S40.txt
lung-landscapes@6
cohortSC0.833
10TCGA-E2-A155-01A-11R-A12D-07
breast-umap@18
B0.826

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 18 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
PROTEIN_SECRETION0.450Remibrutinib— uncovered
ESTROGEN_RESPONSE_EARLY0.260Inavolisib— uncovered
DNA_REPAIR0.230Idelalisib— uncovered
PANCREAS_BETA_CELLS0.190Cobimetinib— uncovered
PEROXISOME0.190Idelalisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.150Remibrutinib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.150Idelalisib— uncovered
MITOTIC_SPINDLE0.140Inavolisib— uncovered
ESTROGEN_RESPONSE_LATE0.130Idelalisib— uncovered
MYC_TARGETS_V10.130Inavolisib— uncovered
BILE_ACID_METABOLISM0.120Inavolisib— uncovered
TGF_BETA_SIGNALING0.120Inavolisib— uncovered
UV_RESPONSE_DN0.120Inavolisib— uncovered
ANDROGEN_RESPONSE0.100Inavolisib— uncovered
MTORC1_SIGNALING0.080Inavolisib— uncovered
NOTCH_SIGNALING0.080Inavolisib— uncovered
GLYCOLYSIS0.030Inavolisib— uncovered
PI3K_AKT_MTOR_SIGNALING0.010Inavolisib— uncovered