Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

ULC1729T_S65

· cohortSQ1

a00038b6-8e6d-583b-a272-c67f3275d813

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
cohortSQ1
subtype
cohortSQ1

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1TCGA-75-7030-01A-11R-1949-07
lung-landscapes@6
cohortA10.961
2TCGA-CR-7393-01A-11R-2016-07
head-neck@1
0.936
3TCGA-56-A4ZJ-01A-11R-A262-07
lung-landscapes@6
cohortSQ10.926
4TCGA-OL-A6VQ-01A-12R-A41B-07
breast-umap@18
A0.924
54c7083b3-eccc-4d80-a31d-6fd3cd0222b4
colon-landscapes@1
0.918
6TCGA-55-8207-01A-11R-2241-07
lung-landscapes@6
cohortA10.917
7SRR12475153
colon-landscapes@1
0.917
8TCGA-A2-A0ES-01A-11R-A115-07
breast-umap@18
A0.916
9TCGA-A2-A0EW-01A-21R-A115-07
breast-umap@18
A0.914
10TCGA-D8-A1JH-01A-11R-A13Q-07
breast-umap@18
A0.911

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 28 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
EPITHELIAL_MESENCHYMAL_TRANSITION0.480Inavolisib— uncovered
NOTCH_SIGNALING0.400Inavolisib— uncovered
UV_RESPONSE_DN0.380Inavolisib— uncovered
TGF_BETA_SIGNALING0.370Inavolisib— uncovered
KRAS_SIGNALING_UP0.360Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.330Idelalisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.330Inavolisib— uncovered
COAGULATION0.320Binimetinib— uncovered
MYOGENESIS0.310Inavolisib— uncovered
HEDGEHOG_SIGNALING0.300Inavolisib— uncovered
IL2_STAT5_SIGNALING0.300Idelalisib— uncovered
IL6_JAK_STAT3_SIGNALING0.300Inavolisib— uncovered
APICAL_JUNCTION0.290Inavolisib— uncovered
COMPLEMENT0.280Inavolisib— uncovered
P53_PATHWAY0.250Idelalisib— uncovered
ANDROGEN_RESPONSE0.240Inavolisib— uncovered
APICAL_SURFACE0.240Temsirolimus— uncovered
HYPOXIA0.220Idelalisib— uncovered
PANCREAS_BETA_CELLS0.200Cobimetinib— uncovered
ANGIOGENESIS0.190Remibrutinib— uncovered