Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-BA-6873-01A-11R-1873-07

a109dcaa-a2a5-5761-ac54-9f9fe10ad6b1

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
sex
male

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • E2F_TARGETS+0.550
  • G2M_CHECKPOINT+0.480
  • MYC_TARGETS_V2+0.470
  • INTERFERON_ALPHA_RESPONSE+0.460
  • MYC_TARGETS_V1+0.410
  • MITOTIC_SPINDLE+0.350
  • WNT_BETA_CATENIN_SIGNALING+0.330
  • INTERFERON_GAMMA_RESPONSE+0.310
  • UNFOLDED_PROTEIN_RESPONSE+0.300
  • EPITHELIAL_MESENCHYMAL_TRANSITION+0.290

Top 10 suppressed

  • REACTIVE_OXYGEN_SPECIES_PATHWAY-0.350
  • OXIDATIVE_PHOSPHORYLATION-0.340
  • ADIPOGENESIS-0.250
  • BILE_ACID_METABOLISM-0.250
  • NOTCH_SIGNALING-0.210
  • XENOBIOTIC_METABOLISM-0.210
  • PEROXISOME-0.180
  • ESTROGEN_RESPONSE_EARLY-0.150
  • CHOLESTEROL_HOMEOSTASIS-0.120
  • P53_PATHWAY-0.110

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1TCGA-85-A511-01A-21R-A262-07
lung-landscapes@6
cohortSQ10.830
2TCGA-CN-5363-01A-01R-1436-07
head-neck@1
0.810
3TCGA-85-7950-01A-11R-2187-07
lung-landscapes@6
cohortSQ10.806
4ERR2208969
melanoma-umap@29
0.802
5GSM5359424
bladder-landscape@3
0.797
602fde1b1-c95c-4d8f-b57b-355b55072108
colon-landscapes@1
0.794
7SRR934755
brain-umap@2
0.793
8TCGA-BH-A0WA-01A-11R-A109-07
breast-umap@18
E0.790
9TCGA-90-7767-01A-11R-2125-07
lung-landscapes@6
cohortSQ10.768
10SRR5088924
melanoma-umap@29
0.767

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 29 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
E2F_TARGETS0.550Inavolisib— uncovered
G2M_CHECKPOINT0.480Inavolisib— uncovered
MYC_TARGETS_V20.470Idelalisib— uncovered
INTERFERON_ALPHA_RESPONSE0.460Inavolisib— uncovered
MYC_TARGETS_V10.410Inavolisib— uncovered
MITOTIC_SPINDLE0.350Inavolisib— uncovered
WNT_BETA_CATENIN_SIGNALING0.330Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.310Idelalisib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.300Idelalisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.290Inavolisib— uncovered
APICAL_SURFACE0.270Temsirolimus— uncovered
TGF_BETA_SIGNALING0.240Inavolisib— uncovered
ANDROGEN_RESPONSE0.230Inavolisib— uncovered
MTORC1_SIGNALING0.230Inavolisib— uncovered
MYOGENESIS0.230Inavolisib— uncovered
IL6_JAK_STAT3_SIGNALING0.190Inavolisib— uncovered
UV_RESPONSE_DN0.180Inavolisib— uncovered
GLYCOLYSIS0.150Inavolisib— uncovered
APICAL_JUNCTION0.140Inavolisib— uncovered
DNA_REPAIR0.120Idelalisib— uncovered