MNG858
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- PANCREAS_BETA_CELLS+0.382
- KRAS_SIGNALING_DN+0.274
- SPERMATOGENESIS+0.262
- APICAL_SURFACE+0.204
- INTERFERON_ALPHA_RESPONSE+0.127
- BILE_ACID_METABOLISM+0.096
- WNT_BETA_CATENIN_SIGNALING+0.015
- HEDGEHOG_SIGNALING+0.004
- INTERFERON_GAMMA_RESPONSE-0.028
- MYOGENESIS-0.039
Top 10 suppressed
- MYC_TARGETS_V2-0.571
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.517
- TGF_BETA_SIGNALING-0.510
- TNFA_SIGNALING_VIA_NFKB-0.475
- UNFOLDED_PROTEIN_RESPONSE-0.473
- DNA_REPAIR-0.455
- OXIDATIVE_PHOSPHORYLATION-0.451
- P53_PATHWAY-0.444
- UV_RESPONSE_UP-0.419
- HYPOXIA-0.418
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
7 twins match this tumor's tissue · 3 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR934970 | — | — | 0.893 |
| 2 | SRR13311161 | — | — | 0.893 |
| 3 | MNG599 | — | — | 0.888 |
| 4 | SRR934844 | — | — | 0.888 |
| 5 | MDT-AP-0706 | Med | Medulloblastoma | 0.884 |
| 6 | MNG189 | — | — | 0.881 |
| 7 | TCGA-49-AARQ-01A-11R-A41B-07 | — | cohortA1 | 0.880 |
| 8 | SRR1473422 | GTEX | — | 0.880 |
| 9 | MNG226 | — | — | 0.880 |
| 10 | BS_0T17SY47 | low-grade glioma | — | 0.879 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 8 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| PANCREAS_BETA_CELLS | 0.382 | Cobimetinib | — uncovered |
| KRAS_SIGNALING_DN | 0.274 | Remibrutinib | — uncovered |
| SPERMATOGENESIS | 0.262 | Inavolisib | — uncovered |
| APICAL_SURFACE | 0.204 | Temsirolimus | — uncovered |
| INTERFERON_ALPHA_RESPONSE | 0.127 | Inavolisib | — uncovered |
| BILE_ACID_METABOLISM | 0.096 | Inavolisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.015 | Inavolisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.004 | Inavolisib | — uncovered |