Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

SRR934900

a2915982-9c80-5fa3-910d-5ba994dc90e7

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
sex
Male

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1SRR934748
brain-umap@2
0.932
2C635C019-A66D-42B7-911C-4D0742CAF95A
brain-umap@2
0.931
3SRR934744
brain-umap@2
0.928
498D004A9-E3F0-448E-BFE2-359F25DF356C
brain-umap@2
0.907
5SRR934990
brain-umap@2
0.905
6SRR934893
brain-umap@2
0.903
7DD5AA3F8-E3EE-4EDD-8152-B1CC07B70A08
brain-umap@2
0.903
8D902E43A-F384-432A-B690-D20BFCC78443
brain-umap@2
0.901
9SRR934902
brain-umap@2
0.897
10SRR934873
brain-umap@2
0.893

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 24 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
E2F_TARGETS0.685Inavolisib— uncovered
G2M_CHECKPOINT0.667Inavolisib— uncovered
MYC_TARGETS_V10.609Inavolisib— uncovered
MYC_TARGETS_V20.603Idelalisib— uncovered
MITOTIC_SPINDLE0.474Inavolisib— uncovered
DNA_REPAIR0.436Idelalisib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.433Idelalisib— uncovered
WNT_BETA_CATENIN_SIGNALING0.338Inavolisib— uncovered
TGF_BETA_SIGNALING0.321Inavolisib— uncovered
MTORC1_SIGNALING0.283Inavolisib— uncovered
ANGIOGENESIS0.248Remibrutinib— uncovered
PROTEIN_SECRETION0.242Remibrutinib— uncovered
NOTCH_SIGNALING0.189Inavolisib— uncovered
UV_RESPONSE_DN0.149Inavolisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.105Inavolisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.061Inavolisib— uncovered
PI3K_AKT_MTOR_SIGNALING0.057Inavolisib— uncovered
ANDROGEN_RESPONSE0.051Inavolisib— uncovered
GLYCOLYSIS0.033Inavolisib— uncovered
HEDGEHOG_SIGNALING0.033Inavolisib— uncovered