Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

← Cohorts · lung-landscapes@6

C3L-01884

— · cohortSQ1

a3ea485d-b155-558a-ad5d-b93433fefb94

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
—
cancer_type_detailed
—
subtype
cohortSQ1
subtype
cohortSQ1
age_years
74.7980835

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

HTTPException: HTTP Error: Request returned HTTP 429 for HTTP HEAD to 'https://pub-e056b053afc04eec88337b62541f3025.r2.dev/oncoscape/lung-landscapes/6/gsva.parquet' LINE 1: SELECT pathway_library_id, pathway_name, gsva_score FROM read_parquet('https://pub-e056b053afc04eec88337b62541f3025... ^

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

9 twins match this tumor's tissue · 1 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1TCGA-NC-A5HM-01A-12R-A26W-07
lung-landscapes@6
—cohortSQ10.832
2SRR1313151
breast-umap@18
—E0.796
3TCGA-NC-A5HN-01A-11R-A26W-07
lung-landscapes@6
—cohortSQ20.767
4SRR25043614
head-neck@1
——0.766
5MNG211
mng-umap@100
——0.766
6MNG358
mng-umap@100
——0.764
7BS_MMNRZ1EQ
brain-umap@2
ATRT—0.758
8MBCProject_0170_T1_RNA
breast-umap@18
—C0.756
9TCGA-58-A46J-01A-11R-A24H-07
lung-landscapes@6
—cohortSQ10.751
10s0094306
melanoma-umap@29
——0.748

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 23 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
E2F_TARGETS0.430Inavolisib— uncovered
G2M_CHECKPOINT0.380Inavolisib— uncovered
MYC_TARGETS_V10.370Inavolisib— uncovered
INTERFERON_ALPHA_RESPONSE0.360Inavolisib— uncovered
MYC_TARGETS_V20.360Idelalisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.290Remibrutinib— uncovered
KRAS_SIGNALING_DN0.220Remibrutinib— uncovered
MTORC1_SIGNALING0.200Inavolisib— uncovered
CHOLESTEROL_HOMEOSTASIS0.190Remibrutinib— uncovered
DNA_REPAIR0.180Idelalisib— uncovered
HEDGEHOG_SIGNALING0.150Inavolisib— uncovered
SPERMATOGENESIS0.140Inavolisib— uncovered
FATTY_ACID_METABOLISM0.130Inavolisib— uncovered
ANGIOGENESIS0.110Remibrutinib— uncovered
INTERFERON_GAMMA_RESPONSE0.100Idelalisib— uncovered
P53_PATHWAY0.090Idelalisib— uncovered
APICAL_SURFACE0.080Temsirolimus— uncovered
GLYCOLYSIS0.080Inavolisib— uncovered
HYPOXIA0.080Idelalisib— uncovered
WNT_BETA_CATENIN_SIGNALING0.080Inavolisib— uncovered