Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-XF-AAMY-01A-11R-A42T-07

a536ebc2-7520-5e0f-958f-054ff3cc6b49

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
overall_survival_months
98.91590013
os_event
false
sex
Male

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • ANGIOGENESIS+0.320
  • EPITHELIAL_MESENCHYMAL_TRANSITION+0.320
  • NOTCH_SIGNALING+0.300
  • MYOGENESIS+0.230
  • APICAL_SURFACE+0.210
  • UV_RESPONSE_DN+0.210
  • APICAL_JUNCTION+0.180
  • TGF_BETA_SIGNALING+0.150
  • SPERMATOGENESIS+0.090
  • COAGULATION+0.040

Top 10 suppressed

  • INTERFERON_ALPHA_RESPONSE-0.580
  • MYC_TARGETS_V1-0.450
  • OXIDATIVE_PHOSPHORYLATION-0.450
  • INTERFERON_GAMMA_RESPONSE-0.420
  • E2F_TARGETS-0.370
  • ALLOGRAFT_REJECTION-0.360
  • MTORC1_SIGNALING-0.360
  • MYC_TARGETS_V2-0.360
  • REACTIVE_OXYGEN_SPECIES_PATHWAY-0.360
  • DNA_REPAIR-0.290

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1X8de42096.ef3e.4864.8ee1.2ee7672c1c82
lung-landscapes@6
cohortSQ10.870
2SRR1313111
breast-umap@18
A0.868
3s0122297
melanoma-umap@29
0.865
4TCGA-CN-4737-01A-01R-1436-07
head-neck@1
0.850
5TCGA-56-8626-01A-11R-2403-07
lung-landscapes@6
cohortSQ10.849
6TCGA-ZF-A9RC-01A-11R-A38B-07
bladder-landscape@3
0.844
7SRR8518437
breast-umap@18
D0.843
8TCGA-DK-A3IQ-01A-31R-A32Y-07
bladder-landscape@3
0.842
9TCGA-CQ-7072-01A-21R-A30B-07
head-neck@1
0.838
10TCGA-AO-A12C-01A-11R-A10J-07
breast-umap@18
A0.838

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 14 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
ANGIOGENESIS0.320Remibrutinib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.320Inavolisib— uncovered
NOTCH_SIGNALING0.300Inavolisib— uncovered
MYOGENESIS0.230Inavolisib— uncovered
APICAL_SURFACE0.210Temsirolimus— uncovered
UV_RESPONSE_DN0.210Inavolisib— uncovered
APICAL_JUNCTION0.180Inavolisib— uncovered
TGF_BETA_SIGNALING0.150Inavolisib— uncovered
SPERMATOGENESIS0.090Inavolisib— uncovered
COAGULATION0.040Binimetinib— uncovered
ESTROGEN_RESPONSE_EARLY0.040Inavolisib— uncovered
KRAS_SIGNALING_UP0.040Inavolisib— uncovered
PI3K_AKT_MTOR_SIGNALING0.020Inavolisib— uncovered
WNT_BETA_CATENIN_SIGNALING0.020Inavolisib— uncovered