Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

BS_8ZS9F31R

high-grade glioma

a53b768e-0421-5521-8171-9e98622b1fae

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
high-grade glioma
cancer_type_detailed
subtype
cancer_type
high-grade glioma
overall_survival_months
32.55584756898817
age_years
10.452
sex
Female

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

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Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

5 twins match this tumor's tissue · 5 come from a different tissue of origin ← cross-tissue dominant

#SampleCancer typeSubtypecos similarity
1BS_3BDAG9YN
brain-umap@2
medulloblastoma0.935
2SRR6013564
lung-landscapes@6
cohortSQ20.918
3BS_M84H3KXA
medullo-epn-umap@date-based
MedMedulloblastoma0.884
4MDT-AP-0322
medullo-epn-umap@date-based
MedMedulloblastoma0.880
5MDT-AP-0359
medullo-epn-umap@date-based
MedMedulloblastoma0.870
6TCGA-E9-A1RB-01A-11R-A157-07
breast-umap@18
C0.869
7MDT-AP-3322
medullo-epn-umap@date-based
MedMedulloblastoma0.858
8MNG1011
mng-umap@100
0.855
9MNG1063
mng-umap@100
0.855
10SRR4195653
colon-landscapes@1
0.853

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 25 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
MYC_TARGETS_V20.765Idelalisib— uncovered
MYC_TARGETS_V10.726Inavolisib— uncovered
E2F_TARGETS0.669Inavolisib— uncovered
G2M_CHECKPOINT0.608Inavolisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.583Remibrutinib— uncovered
MTORC1_SIGNALING0.466Inavolisib— uncovered
DNA_REPAIR0.414Idelalisib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.403Idelalisib— uncovered
PI3K_AKT_MTOR_SIGNALING0.295Inavolisib— uncovered
GLYCOLYSIS0.245Inavolisib— uncovered
PROTEIN_SECRETION0.216Remibrutinib— uncovered
ANDROGEN_RESPONSE0.214Inavolisib— uncovered
ADIPOGENESIS0.196Inavolisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.179Inavolisib— uncovered
ANGIOGENESIS0.177Remibrutinib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.170Inavolisib— uncovered
FATTY_ACID_METABOLISM0.158Inavolisib— uncovered
PEROXISOME0.146Idelalisib— uncovered
P53_PATHWAY0.130Idelalisib— uncovered
MITOTIC_SPINDLE0.099Inavolisib— uncovered