Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-OL-A66P-01A-11R-A31O-07

· B

a55cff72-0b6a-54c5-9cfa-4f54cac0c3b2

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
B
subtype
B
overall_survival_months
14
os_event
false

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • ALLOGRAFT_REJECTION+0.550
  • XENOBIOTIC_METABOLISM+0.410
  • INTERFERON_GAMMA_RESPONSE+0.390
  • INFLAMMATORY_RESPONSE+0.380
  • CHOLESTEROL_HOMEOSTASIS+0.370
  • IL2_STAT5_SIGNALING+0.360
  • OXIDATIVE_PHOSPHORYLATION+0.360
  • COAGULATION+0.340
  • FATTY_ACID_METABOLISM+0.330
  • REACTIVE_OXYGEN_SPECIES_PATHWAY+0.330

Top 10 suppressed

  • MITOTIC_SPINDLE-0.480
  • PROTEIN_SECRETION-0.480
  • TGF_BETA_SIGNALING-0.440
  • G2M_CHECKPOINT-0.420
  • UV_RESPONSE_DN-0.370
  • WNT_BETA_CATENIN_SIGNALING-0.360
  • E2F_TARGETS-0.350
  • NOTCH_SIGNALING-0.340
  • ESTROGEN_RESPONSE_EARLY-0.220
  • MYC_TARGETS_V1-0.210

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

6 twins match this tumor's tissue · 4 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1da7cbc0a-95dc-4303-a5dd-75857c066f3b
melanoma-umap@29
0.855
2TCGA-BH-A5J0-01A-11R-A27Q-07
breast-umap@18
B0.847
3d3be84d5-9dd7-4366-9aea-532dc76f19ba
melanoma-umap@29
0.841
4TCGA-BH-A0AW-01A-11R-A056-07
breast-umap@18
C0.838
5SAMN03290925
melanoma-umap@29
0.836
6BS_6NTXGQAC
brain-umap@2
Ganglioglioma0.834
7MDT-AP-2183
medullo-epn-umap@date-based
MedMedulloblastoma0.831
8SJEPD001516_D1.RNA-Seq
medullo-epn-umap@date-based
EPNPosterior Fossa EPN0.829
9ERR2598280
medullo-epn-umap@date-based
fetalfetal0.829
10TCGA-AC-A5XS-01A-11R-A29R-07
breast-umap@18
B0.819

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 32 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
ALLOGRAFT_REJECTION0.550Idelalisib— uncovered
XENOBIOTIC_METABOLISM0.410Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.390Idelalisib— uncovered
INFLAMMATORY_RESPONSE0.380Idelalisib— uncovered
CHOLESTEROL_HOMEOSTASIS0.370Remibrutinib— uncovered
IL2_STAT5_SIGNALING0.360Idelalisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.360Remibrutinib— uncovered
COAGULATION0.340Binimetinib— uncovered
FATTY_ACID_METABOLISM0.330Inavolisib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.330Inavolisib— uncovered
ADIPOGENESIS0.320Inavolisib— uncovered
IL6_JAK_STAT3_SIGNALING0.320Inavolisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.320Inavolisib— uncovered
P53_PATHWAY0.310Idelalisib— uncovered
KRAS_SIGNALING_UP0.300Inavolisib— uncovered
COMPLEMENT0.280Inavolisib— uncovered
BILE_ACID_METABOLISM0.270Inavolisib— uncovered
MYOGENESIS0.260Inavolisib— uncovered
UV_RESPONSE_UP0.260Idelalisib— uncovered
INTERFERON_ALPHA_RESPONSE0.240Inavolisib— uncovered