Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

← Cohorts · lung-landscapes@6

SRR6013583

— · cohortA1

a5966cc6-e7a0-5332-864a-ac2fe07ab2a1

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
—
cancer_type_detailed
—
subtype
cohortA1
subtype
cohortA1

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • UV_RESPONSE_DN+0.360
  • NOTCH_SIGNALING+0.330
  • INTERFERON_ALPHA_RESPONSE+0.250
  • EPITHELIAL_MESENCHYMAL_TRANSITION+0.240
  • TGF_BETA_SIGNALING+0.240
  • INTERFERON_GAMMA_RESPONSE+0.200
  • WNT_BETA_CATENIN_SIGNALING+0.190
  • IL2_STAT5_SIGNALING+0.180
  • APOPTOSIS+0.140
  • IL6_JAK_STAT3_SIGNALING+0.130

Top 10 suppressed

  • MYC_TARGETS_V2-0.510
  • MYC_TARGETS_V1-0.450
  • PANCREAS_BETA_CELLS-0.420
  • E2F_TARGETS-0.400
  • MTORC1_SIGNALING-0.400
  • CHOLESTEROL_HOMEOSTASIS-0.340
  • UNFOLDED_PROTEIN_RESPONSE-0.340
  • G2M_CHECKPOINT-0.330
  • OXIDATIVE_PHOSPHORYLATION-0.310
  • DNA_REPAIR-0.270

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1102d912c-5882-4ae4-9eaf-cbd2f55f66af
melanoma-umap@29
——0.850
2TCGA-55-A57B-01A-12R-A39D-07
lung-landscapes@6
—cohortA10.840
3SRR6013595
lung-landscapes@6
—cohortA10.833
4SRR6013599
lung-landscapes@6
—cohortMD20.829
5AUR-AG12-TTP1-A-1-0-R-A741-41
breast-umap@18
—A0.824
6TCGA-86-8668-01A-11R-2403-07
lung-landscapes@6
—cohortA10.824
7SRR35579832
breast-umap@18
—A0.821
8SRR35579838
breast-umap@18
—D0.820
9TCGA-B6-A0IH-01A-11R-A115-07
breast-umap@18
—A0.804
10X11c86678.2438.485c.a672.d578e14b8013
lung-landscapes@6
—cohortA10.803

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 19 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
UV_RESPONSE_DN0.360Inavolisib— uncovered
NOTCH_SIGNALING0.330Inavolisib— uncovered
INTERFERON_ALPHA_RESPONSE0.250Inavolisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.240Inavolisib— uncovered
TGF_BETA_SIGNALING0.240Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.200Idelalisib— uncovered
WNT_BETA_CATENIN_SIGNALING0.190Inavolisib— uncovered
IL2_STAT5_SIGNALING0.180Idelalisib— uncovered
APOPTOSIS0.140Idelalisib— uncovered
IL6_JAK_STAT3_SIGNALING0.130Inavolisib— uncovered
KRAS_SIGNALING_UP0.110Inavolisib— uncovered
MITOTIC_SPINDLE0.110Inavolisib— uncovered
HEDGEHOG_SIGNALING0.100Inavolisib— uncovered
APICAL_JUNCTION0.090Inavolisib— uncovered
MYOGENESIS0.080Inavolisib— uncovered
PROTEIN_SECRETION0.080Remibrutinib— uncovered
APICAL_SURFACE0.030Temsirolimus— uncovered
P53_PATHWAY0.030Idelalisib— uncovered
ESTROGEN_RESPONSE_EARLY0.010Inavolisib— uncovered