Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.
KIRhub 2.0
Sign in

ea89121f-2c74-433d-8047-898dc963bf35

a5b2f46e-f8ca-59d7-b455-fdf86b157095

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
age_years
71.5318275154004

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • MYOGENESIS+0.410
  • PANCREAS_BETA_CELLS+0.260
  • WNT_BETA_CATENIN_SIGNALING+0.240
  • KRAS_SIGNALING_DN+0.170
  • UV_RESPONSE_DN+0.170
  • TGF_BETA_SIGNALING+0.120
  • HEDGEHOG_SIGNALING+0.110
  • SPERMATOGENESIS+0.110
  • APICAL_JUNCTION+0.100
  • UV_RESPONSE_UP+0.020

Top 10 suppressed

  • ALLOGRAFT_REJECTION-0.550
  • IL6_JAK_STAT3_SIGNALING-0.540
  • INFLAMMATORY_RESPONSE-0.520
  • INTERFERON_GAMMA_RESPONSE-0.500
  • TNFA_SIGNALING_VIA_NFKB-0.480
  • INTERFERON_ALPHA_RESPONSE-0.420
  • COMPLEMENT-0.390
  • CHOLESTEROL_HOMEOSTASIS-0.360
  • MTORC1_SIGNALING-0.360
  • FATTY_ACID_METABOLISM-0.350

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

9 twins match this tumor's tissue · 1 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1ca7ac1e1-4c44-40a5-8094-eeebc0c2c5a2
colon-landscapes@1
0.876
2TCGA-CN-A49A-01A-11R-A24H-07
head-neck@1
0.874
3ERR2598227
medullo-epn-umap@date-based
fetalfetal0.845
4TCGA-90-A4ED-01A-31R-A24Z-07
lung-landscapes@6
cohortMD10.843
5e3d71c3f-4e56-45fa-be88-2cf444b70a5c
melanoma-umap@29
0.839
6SRR8392885
lung-landscapes@6
cohortA30.838
7SRR4195662
colon-landscapes@1
0.838
8ca7940e6-af7e-44fd-a6fc-5d86dc1d86c4
colon-landscapes@1
0.837
9AUR-AD9E-TTM2-A-1-1-R-A542-39
breast-umap@18
B0.837
10MBCProject_0589_T1_RNA
breast-umap@18
A0.834