Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

← Cohorts · breast-umap@18

SRR8518386

— · D

aa0f9952-cf6c-5e64-abf5-9559188f445e

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
—
cancer_type_detailed
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subtype
D
subtype
D

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1ff12dc45-d7ab-45ae-a049-2d20e3c546b6
melanoma-umap@29
——0.859
2TCGA-E9-A243-01A-21R-A169-07
breast-umap@18
—D0.858
3SRR8518312
breast-umap@18
—D0.858
4SRR2932829
head-neck@1
——0.847
5SRR8518190
breast-umap@18
—D0.831
6ULC0563T_S23
lung-landscapes@6
—cohortMD20.825
7SRR8613787
breast-umap@18
—D0.802
8SRR8518332
breast-umap@18
—D0.798
9SRR8613712
breast-umap@18
—D0.798
10SRR8518400
breast-umap@18
—D0.792

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 22 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
INTERFERON_ALPHA_RESPONSE0.750Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.660Idelalisib— uncovered
ALLOGRAFT_REJECTION0.480Idelalisib— uncovered
COMPLEMENT0.380Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.380Idelalisib— uncovered
IL6_JAK_STAT3_SIGNALING0.370Inavolisib— uncovered
PROTEIN_SECRETION0.330Remibrutinib— uncovered
IL2_STAT5_SIGNALING0.220Idelalisib— uncovered
PANCREAS_BETA_CELLS0.220Cobimetinib— uncovered
KRAS_SIGNALING_UP0.210Inavolisib— uncovered
COAGULATION0.160Binimetinib— uncovered
MYC_TARGETS_V10.150Inavolisib— uncovered
APOPTOSIS0.130Idelalisib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.090Idelalisib— uncovered
ANDROGEN_RESPONSE0.070Inavolisib— uncovered
MTORC1_SIGNALING0.070Inavolisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.070Inavolisib— uncovered
SPERMATOGENESIS0.060Inavolisib— uncovered
PI3K_AKT_MTOR_SIGNALING0.040Inavolisib— uncovered
UV_RESPONSE_DN0.040Inavolisib— uncovered