20050089.Her2HRneg
— · C
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- C
- subtype
- C
GSVA pathway preview (0 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
6 twins match this tumor's tissue · 4 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | 20030075.TNBC | — | C | 0.860 |
| 2 | SRR8518423 | — | C | 0.829 |
| 3 | TCGA-55-6982-01A-11R-1949-07 | — | cohortA1 | 0.816 |
| 4 | BS_WRHDP7WF | Posterior Fossa Ependymoma | — | 0.815 |
| 5 | b428d434-2904-4f67-a66f-b7928e2951e3 | — | — | 0.814 |
| 6 | BS_51RA1PGE | high-grade glioma | — | 0.813 |
| 7 | SNU475_LIVER | HCC | — | 0.809 |
| 8 | BS_VP3C8WZT | pilocytic astrocytoma | — | 0.801 |
| 9 | TCGA-CV-7433-01A-11R-2132-07 | — | — | 0.792 |
| 10 | TCGA-D8-A1JK-01A-11R-A13Q-07 | — | C | 0.791 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 42 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| INTERFERON_ALPHA_RESPONSE | 0.670 | Inavolisib | — uncovered |
| EPITHELIAL_MESENCHYMAL_TRANSITION | 0.560 | Inavolisib | — uncovered |
| INTERFERON_GAMMA_RESPONSE | 0.500 | Idelalisib | — uncovered |
| ANGIOGENESIS | 0.480 | Remibrutinib | — uncovered |
| GLYCOLYSIS | 0.440 | Inavolisib | — uncovered |
| CHOLESTEROL_HOMEOSTASIS | 0.410 | Remibrutinib | — uncovered |
| HYPOXIA | 0.370 | Idelalisib | — uncovered |
| INFLAMMATORY_RESPONSE | 0.360 | Idelalisib | — uncovered |
| MYOGENESIS | 0.360 | Inavolisib | — uncovered |
| XENOBIOTIC_METABOLISM | 0.350 | Inavolisib | — uncovered |
| COAGULATION | 0.300 | Binimetinib | — uncovered |
| FATTY_ACID_METABOLISM | 0.300 | Inavolisib | — uncovered |
| IL6_JAK_STAT3_SIGNALING | 0.300 | Inavolisib | — uncovered |
| APICAL_JUNCTION | 0.290 | Inavolisib | — uncovered |
| MTORC1_SIGNALING | 0.290 | Inavolisib | — uncovered |
| APICAL_SURFACE | 0.280 | Temsirolimus | — uncovered |
| PROTEIN_SECRETION | 0.280 | Remibrutinib | — uncovered |
| ADIPOGENESIS | 0.270 | Inavolisib | — uncovered |
| UV_RESPONSE_DN | 0.230 | Inavolisib | — uncovered |
| COMPLEMENT | 0.210 | Inavolisib | — uncovered |