Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-AN-A03X-01A-21R-A00Z-07

· A

ab2723fb-0565-55c4-a64c-9504a207a8f7

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
A
subtype
A
overall_survival_months
0
os_event
false

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • EPITHELIAL_MESENCHYMAL_TRANSITION+0.640
  • ANGIOGENESIS+0.580
  • COAGULATION+0.430
  • PANCREAS_BETA_CELLS+0.420
  • UV_RESPONSE_DN+0.410
  • ANDROGEN_RESPONSE+0.350
  • APICAL_SURFACE+0.350
  • ESTROGEN_RESPONSE_EARLY+0.350
  • MYOGENESIS+0.330
  • APOPTOSIS+0.320

Top 10 suppressed

  • G2M_CHECKPOINT-0.450
  • E2F_TARGETS-0.420
  • MYC_TARGETS_V1-0.260
  • PI3K_AKT_MTOR_SIGNALING-0.240
  • MITOTIC_SPINDLE-0.230
  • MYC_TARGETS_V2-0.230
  • WNT_BETA_CATENIN_SIGNALING-0.180
  • DNA_REPAIR-0.160
  • ALLOGRAFT_REJECTION-0.140
  • SPERMATOGENESIS-0.130

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1SRR8518353
breast-umap@18
F0.910
2s0099997
melanoma-umap@29
0.889
3C3N-04173
lung-landscapes@6
cohortA20.886
4MNG1284
mng-umap@100
0.882
5SRR15030843
colon-landscapes@1
0.881
6TCGA-A2-A0EO-01A-11R-A034-07
breast-umap@18
A0.869
7TCGA-BH-A0HF-01A-11R-A056-07
breast-umap@18
A0.866
8TCGA-22-4605-01A-21R-2125-07
lung-landscapes@6
cohortSQ10.861
9MNG349
mng-umap@100
0.857
10SRR8613755
breast-umap@18
F0.850

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 38 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
EPITHELIAL_MESENCHYMAL_TRANSITION0.640Inavolisib— uncovered
ANGIOGENESIS0.580Remibrutinib— uncovered
COAGULATION0.430Binimetinib— uncovered
PANCREAS_BETA_CELLS0.420Cobimetinib— uncovered
UV_RESPONSE_DN0.410Inavolisib— uncovered
ANDROGEN_RESPONSE0.350Inavolisib— uncovered
APICAL_SURFACE0.350Temsirolimus— uncovered
ESTROGEN_RESPONSE_EARLY0.350Inavolisib— uncovered
MYOGENESIS0.330Inavolisib— uncovered
APOPTOSIS0.320Idelalisib— uncovered
HYPOXIA0.310Idelalisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.310Inavolisib— uncovered
APICAL_JUNCTION0.280Inavolisib— uncovered
CHOLESTEROL_HOMEOSTASIS0.280Remibrutinib— uncovered
XENOBIOTIC_METABOLISM0.280Inavolisib— uncovered
TGF_BETA_SIGNALING0.260Inavolisib— uncovered
BILE_ACID_METABOLISM0.250Inavolisib— uncovered
COMPLEMENT0.250Inavolisib— uncovered
ESTROGEN_RESPONSE_LATE0.250Idelalisib— uncovered
KRAS_SIGNALING_UP0.250Inavolisib— uncovered