Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

ERR2598283

fetal · fetal

afdd8677-e23d-52b4-bfd7-49e3f471fba1

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
fetal
cancer_type_detailed
subtype
fetal
cancer_type
fetal
subtype
fetal
sex
fetal
race
fetal
fetal_age_hindbrain
25
umap1_2d
-4.586063788
umap2_2d
-3.859138855
umap1_3d
3.990132304
umap2_3d
1.663583519
umap3_3d
-0.724682931
dataset
fetal

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

5 twins match this tumor's tissue · 5 come from a different tissue of origin ← cross-tissue dominant

#SampleCancer typeSubtypecos similarity
1TCGA-OR-A5L5-01
acc-tcga-pancan-2018@2018
Adrenocortical CarcinomaAdrenocortical Carcinoma, Usual Type0.897
2SJEPD031138_D2.RNA-Seq
medullo-epn-umap@date-based
EPNSupratentorial EPN0.889
3ERR2598341
medullo-epn-umap@date-based
fetalfetal0.888
4ERR2598329
medullo-epn-umap@date-based
fetalfetal0.875
5MDT-AP-2055
medullo-epn-umap@date-based
MedMedulloblastoma0.872
6ERR2598268
medullo-epn-umap@date-based
fetalfetal0.869
7ERR2598328
medullo-epn-umap@date-based
fetalfetal0.867
8TCGA-DQ-5630-01A-01R-1873-07
head-neck@1
0.863
9BS_ARBQDTT5
brain-umap@2
pilocytic astrocytoma0.860
10SRR1435753
brain-umap@2
GTEX0.859

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 31 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
INTERFERON_ALPHA_RESPONSE0.520Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.490Idelalisib— uncovered
ALLOGRAFT_REJECTION0.440Idelalisib— uncovered
INFLAMMATORY_RESPONSE0.380Idelalisib— uncovered
IL6_JAK_STAT3_SIGNALING0.360Inavolisib— uncovered
COMPLEMENT0.350Inavolisib— uncovered
COAGULATION0.300Binimetinib— uncovered
OXIDATIVE_PHOSPHORYLATION0.290Remibrutinib— uncovered
BILE_ACID_METABOLISM0.270Inavolisib— uncovered
KRAS_SIGNALING_UP0.260Inavolisib— uncovered
KRAS_SIGNALING_DN0.250Remibrutinib— uncovered
MYOGENESIS0.250Inavolisib— uncovered
PROTEIN_SECRETION0.240Remibrutinib— uncovered
APOPTOSIS0.230Idelalisib— uncovered
XENOBIOTIC_METABOLISM0.210Inavolisib— uncovered
IL2_STAT5_SIGNALING0.200Idelalisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.200Inavolisib— uncovered
FATTY_ACID_METABOLISM0.190Inavolisib— uncovered
ADIPOGENESIS0.150Inavolisib— uncovered
ANDROGEN_RESPONSE0.150Inavolisib— uncovered