Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-BH-A0EA-01A-11R-A115-07

· A

b18a109b-d529-51e2-b404-c4cf8168b23c

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
A
subtype
A
overall_survival_months
33

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1MBCProject_7544_T2_RNA
breast-umap@18
A0.938
2SRR8613732
breast-umap@18
A0.933
3TCGA-HN-A2OB-01A-21R-A27Q-07
breast-umap@18
A0.929
4TCGA-BH-A28O-01A-11R-A22K-07
breast-umap@18
A0.917
5SRR1313091
breast-umap@18
A0.891
6TCGA-A2-A0EW-01A-21R-A115-07
breast-umap@18
A0.886
7MBCProject_0063_T3A_RNA
breast-umap@18
A0.883
820050037.TNBC
breast-umap@18
C0.881
9SRR35579834
breast-umap@18
A0.878
10BSR_05_0025_A4_S57
breast-umap@18
A0.877

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 24 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
HEDGEHOG_SIGNALING0.430Inavolisib— uncovered
MYOGENESIS0.430Inavolisib— uncovered
WNT_BETA_CATENIN_SIGNALING0.430Inavolisib— uncovered
UV_RESPONSE_DN0.420Inavolisib— uncovered
APICAL_SURFACE0.380Temsirolimus— uncovered
APICAL_JUNCTION0.360Inavolisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.350Inavolisib— uncovered
TGF_BETA_SIGNALING0.310Inavolisib— uncovered
COAGULATION0.270Binimetinib— uncovered
ANGIOGENESIS0.250Remibrutinib— uncovered
KRAS_SIGNALING_UP0.250Inavolisib— uncovered
ADIPOGENESIS0.210Inavolisib— uncovered
HYPOXIA0.190Idelalisib— uncovered
NOTCH_SIGNALING0.190Inavolisib— uncovered
BILE_ACID_METABOLISM0.180Inavolisib— uncovered
HEME_METABOLISM0.160Temsirolimus— uncovered
TNFA_SIGNALING_VIA_NFKB0.160Inavolisib— uncovered
XENOBIOTIC_METABOLISM0.150Inavolisib— uncovered
PANCREAS_BETA_CELLS0.130Cobimetinib— uncovered
P53_PATHWAY0.110Idelalisib— uncovered