20040026.LumA
— · B
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- B
- subtype
- B
GSVA pathway preview (0 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
8 twins match this tumor's tissue · 2 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | TCGA-86-8076-01A-31R-2241-07 | — | cohortA1 | 0.807 |
| 2 | TCGA-44-2661-01A-01R-1107-07 | — | cohortA1 | 0.795 |
| 3 | SRR8518296 | — | A | 0.791 |
| 4 | MDT-AP-0377 | Med | Medulloblastoma | 0.787 |
| 5 | TCGA-62-A46Y-01A-11R-A24H-07 | — | cohortA1 | 0.780 |
| 6 | TCGA-EW-A2FS-01A-11R-A17B-07 | — | B | 0.780 |
| 7 | TCGA-AC-A6IX-06A-11R-A32P-07 | — | D | 0.776 |
| 8 | SRR2932840 | — | — | 0.776 |
| 9 | TCGA-OR-A5LN-01 | Adrenocortical Carcinoma | Adrenocortical Carcinoma, Usual Type | 0.771 |
| 10 | SRR33532817 | — | D | 0.770 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 11 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| ALLOGRAFT_REJECTION | 0.330 | Idelalisib | — uncovered |
| INTERFERON_ALPHA_RESPONSE | 0.220 | Inavolisib | — uncovered |
| INTERFERON_GAMMA_RESPONSE | 0.210 | Idelalisib | — uncovered |
| APOPTOSIS | 0.200 | Idelalisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.180 | Remibrutinib | — uncovered |
| INFLAMMATORY_RESPONSE | 0.120 | Idelalisib | — uncovered |
| IL6_JAK_STAT3_SIGNALING | 0.100 | Inavolisib | — uncovered |
| P53_PATHWAY | 0.080 | Idelalisib | — uncovered |
| COMPLEMENT | 0.070 | Inavolisib | — uncovered |
| TNFA_SIGNALING_VIA_NFKB | 0.060 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_EARLY | 0.050 | Inavolisib | — uncovered |