Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

← Cohorts · mng-umap@100

MNG1023

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b34c5726-7cd2-521d-abba-dfca388a7c47

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
—
cancer_type_detailed
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subtype
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GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • PROTEIN_SECRETION+0.524
  • TGF_BETA_SIGNALING+0.432
  • ANDROGEN_RESPONSE+0.430
  • CHOLESTEROL_HOMEOSTASIS+0.421
  • PEROXISOME+0.387
  • MITOTIC_SPINDLE+0.378
  • APICAL_SURFACE+0.375
  • UV_RESPONSE_DN+0.366
  • ESTROGEN_RESPONSE_EARLY+0.360
  • MTORC1_SIGNALING+0.322

Top 10 suppressed

  • MYC_TARGETS_V2-0.368
  • PANCREAS_BETA_CELLS-0.279
  • OXIDATIVE_PHOSPHORYLATION-0.247
  • INTERFERON_ALPHA_RESPONSE-0.069
  • UV_RESPONSE_UP-0.066
  • SPERMATOGENESIS-0.063
  • WNT_BETA_CATENIN_SIGNALING-0.055
  • KRAS_SIGNALING_DN-0.029
  • INTERFERON_GAMMA_RESPONSE-0.022
  • DNA_REPAIR+0.026

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1TCGA-60-2707-01A-01R-0851-07
lung-landscapes@6
—cohortSQ10.824
2MNG1059
mng-umap@100
——0.821
3MNG1012
mng-umap@100
——0.819
4TCGA-R3-A69X-01A-22R-A30C-07
bladder-landscape@3
——0.817
5TCGA-77-7338-01A-11R-2045-07
lung-landscapes@6
—cohortSQ20.813
6SRR13311168
bladder-landscape@3
——0.809
78D30F824-25B9-43DB-BD39-2C9C790509DD
brain-umap@2
——0.805
8MNG223
mng-umap@100
——0.794
9D65697C7-2DA7-43BA-ABE2-50CB08B0D126
brain-umap@2
——0.791
10TCGA-A1-A0SJ-01A-11R-A084-07
breast-umap@18
—B0.786

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 41 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
PROTEIN_SECRETION0.524Remibrutinib— uncovered
TGF_BETA_SIGNALING0.432Inavolisib— uncovered
ANDROGEN_RESPONSE0.430Inavolisib— uncovered
CHOLESTEROL_HOMEOSTASIS0.421Remibrutinib— uncovered
PEROXISOME0.387Idelalisib— uncovered
MITOTIC_SPINDLE0.378Inavolisib— uncovered
APICAL_SURFACE0.375Temsirolimus— uncovered
UV_RESPONSE_DN0.366Inavolisib— uncovered
ESTROGEN_RESPONSE_EARLY0.360Inavolisib— uncovered
MTORC1_SIGNALING0.322Inavolisib— uncovered
HYPOXIA0.307Idelalisib— uncovered
APOPTOSIS0.288Idelalisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.288Inavolisib— uncovered
ANGIOGENESIS0.285Remibrutinib— uncovered
GLYCOLYSIS0.285Inavolisib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.277Idelalisib— uncovered
BILE_ACID_METABOLISM0.276Inavolisib— uncovered
APICAL_JUNCTION0.257Inavolisib— uncovered
HEME_METABOLISM0.242Temsirolimus— uncovered
PI3K_AKT_MTOR_SIGNALING0.231Inavolisib— uncovered