Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-DK-AA77-01A-11R-A39I-07

b39f14a2-a4f6-58a1-a628-9537fab71c53

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
overall_survival_months
20.3022339
os_event
false
sex
Male

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • UNFOLDED_PROTEIN_RESPONSE+0.490
  • INTERFERON_ALPHA_RESPONSE+0.440
  • MTORC1_SIGNALING+0.440
  • MYC_TARGETS_V1+0.440
  • PROTEIN_SECRETION+0.420
  • ANDROGEN_RESPONSE+0.390
  • CHOLESTEROL_HOMEOSTASIS+0.340
  • INTERFERON_GAMMA_RESPONSE+0.330
  • OXIDATIVE_PHOSPHORYLATION+0.320
  • ADIPOGENESIS+0.310

Top 10 suppressed

  • EPITHELIAL_MESENCHYMAL_TRANSITION-0.520
  • PANCREAS_BETA_CELLS-0.490
  • ANGIOGENESIS-0.430
  • COAGULATION-0.320
  • HEDGEHOG_SIGNALING-0.320
  • WNT_BETA_CATENIN_SIGNALING-0.300
  • MYOGENESIS-0.290
  • APICAL_JUNCTION-0.240
  • APICAL_SURFACE-0.240
  • KRAS_SIGNALING_DN-0.200

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

7 twins match this tumor's tissue · 3 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1R190
bladder-landscape@3
0.873
2TCGA-A2-A0YT-01A-11R-A109-07
breast-umap@18
B0.843
3BS_W80TJC27
brain-umap@2
Supratentorial Ependymoma0.842
4SRR650153
bladder-landscape@3
0.818
5BS_W80TJC27
medullo-epn-umap@date-based
EPNSupratentorial EPN0.816
6TCGA-HQ-A5ND-01A-11R-A26T-07
bladder-landscape@3
0.813
781b828aa-cb06-4790-ba3e-efaa39f4eeef
colon-landscapes@1
0.813
8BS_CZ3ER8DY
brain-umap@2
Supratentorial Ependymoma0.808
9TCGA-CQ-6220-01A-11R-1915-07
head-neck@1
0.802
10R128
bladder-landscape@3
0.801

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 30 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
UNFOLDED_PROTEIN_RESPONSE0.490Idelalisib— uncovered
INTERFERON_ALPHA_RESPONSE0.440Inavolisib— uncovered
MTORC1_SIGNALING0.440Inavolisib— uncovered
MYC_TARGETS_V10.440Inavolisib— uncovered
PROTEIN_SECRETION0.420Remibrutinib— uncovered
ANDROGEN_RESPONSE0.390Inavolisib— uncovered
CHOLESTEROL_HOMEOSTASIS0.340Remibrutinib— uncovered
INTERFERON_GAMMA_RESPONSE0.330Idelalisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.320Remibrutinib— uncovered
ADIPOGENESIS0.310Inavolisib— uncovered
PI3K_AKT_MTOR_SIGNALING0.300Inavolisib— uncovered
E2F_TARGETS0.280Inavolisib— uncovered
G2M_CHECKPOINT0.280Inavolisib— uncovered
GLYCOLYSIS0.260Inavolisib— uncovered
PEROXISOME0.240Idelalisib— uncovered
DNA_REPAIR0.220Idelalisib— uncovered
ESTROGEN_RESPONSE_EARLY0.210Inavolisib— uncovered
HYPOXIA0.200Idelalisib— uncovered
MYC_TARGETS_V20.200Idelalisib— uncovered
FATTY_ACID_METABOLISM0.150Inavolisib— uncovered