Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

0D8C7EC1-9BFB-44A1-8AF8-05D2A6BBE0F9

b41d68c9-c80a-5ca4-96eb-52391b5ce03d

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
overall_survival_months
9.42838370565046
age_years
33
sex
Male

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

8 twins match this tumor's tissue · 2 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1167869B6-9620-445E-BA77-B6F95A6463F5
brain-umap@2
0.918
26819D9DA-FE18-4584-8AF6-E53DD894852E
brain-umap@2
0.887
3ERR2598195
medullo-epn-umap@date-based
fetalfetal0.883
49CC5EB30-A8C2-4FDF-8074-467AA98ED1CA
brain-umap@2
0.881
59F204EEA-9026-4367-8586-C2127D55AC5E
brain-umap@2
0.881
60730F3DB-384B-43E6-A69F-BF3F7C2CCE78
brain-umap@2
0.880
7ERR2598213
medullo-epn-umap@date-based
fetalfetal0.869
8TCGA-BH-A0HL-01A-11R-A10U-07
breast-umap@18
B0.869
9E3818BAA-BA28-4CE4-A745-BB3692883888
brain-umap@2
0.868
107DC6D598-8506-4680-81DF-C1D0F1B5C27D
brain-umap@2
0.868

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 18 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
HEDGEHOG_SIGNALING0.437Inavolisib— uncovered
WNT_BETA_CATENIN_SIGNALING0.333Inavolisib— uncovered
MYC_TARGETS_V20.270Idelalisib— uncovered
MITOTIC_SPINDLE0.257Inavolisib— uncovered
NOTCH_SIGNALING0.241Inavolisib— uncovered
DNA_REPAIR0.210Idelalisib— uncovered
PANCREAS_BETA_CELLS0.206Cobimetinib— uncovered
G2M_CHECKPOINT0.195Inavolisib— uncovered
PROTEIN_SECRETION0.158Remibrutinib— uncovered
E2F_TARGETS0.152Inavolisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.127Remibrutinib— uncovered
TGF_BETA_SIGNALING0.098Inavolisib— uncovered
CHOLESTEROL_HOMEOSTASIS0.095Remibrutinib— uncovered
UV_RESPONSE_DN0.085Inavolisib— uncovered
ESTROGEN_RESPONSE_EARLY0.043Inavolisib— uncovered
MTORC1_SIGNALING0.030Inavolisib— uncovered
APICAL_SURFACE0.004Temsirolimus— uncovered
UV_RESPONSE_UP0.002Idelalisib— uncovered