BS_MVW01FPB
ATRT
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- ATRT
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- ATRT
- overall_survival_months
- 17.181340341655716
- age_years
- 0.521
- sex
- Female
GSVA pathway preview (0 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
9 twins match this tumor's tissue · 1 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | MNG1194 | — | — | 0.901 |
| 2 | BS_MV6ASWV9 | ATRT | — | 0.887 |
| 3 | AUR-AG0N-TTM1-A-1-1-R-A743-41 | — | E | 0.885 |
| 4 | SRR2016947 | — | — | 0.883 |
| 5 | C3L-01285 | — | cohortSQ2 | 0.882 |
| 6 | SRR10900561 | — | — | 0.881 |
| 7 | 064ec215-7600-4e5d-be51-e757284f3e54 | — | — | 0.878 |
| 8 | TCGA-63-A5M9-01A-11R-A26W-07 | — | cohortSQ2 | 0.876 |
| 9 | BS_R439VVPK | medulloblastoma | — | 0.874 |
| 10 | MNG737 | — | — | 0.873 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 16 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| E2F_TARGETS | 0.601 | Inavolisib | — uncovered |
| MYC_TARGETS_V1 | 0.561 | Inavolisib | — uncovered |
| G2M_CHECKPOINT | 0.508 | Inavolisib | — uncovered |
| MYC_TARGETS_V2 | 0.385 | Idelalisib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.334 | Idelalisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.323 | Remibrutinib | — uncovered |
| MTORC1_SIGNALING | 0.245 | Inavolisib | — uncovered |
| MITOTIC_SPINDLE | 0.228 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.183 | Inavolisib | — uncovered |
| DNA_REPAIR | 0.140 | Idelalisib | — uncovered |
| CHOLESTEROL_HOMEOSTASIS | 0.135 | Remibrutinib | — uncovered |
| NOTCH_SIGNALING | 0.089 | Inavolisib | — uncovered |
| APICAL_SURFACE | 0.070 | Temsirolimus | — uncovered |
| GLYCOLYSIS | 0.031 | Inavolisib | — uncovered |
| HYPOXIA | 0.008 | Idelalisib | — uncovered |
| ANGIOGENESIS | 0.001 | Remibrutinib | — uncovered |