Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-BH-A1F8-01A-11R-A13Q-07

· B

b52514b8-8553-57f5-89df-25cfae0f5b33

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
B
subtype
B
overall_survival_months
0

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • PROTEIN_SECRETION+0.540
  • INTERFERON_ALPHA_RESPONSE+0.450
  • MTORC1_SIGNALING+0.360
  • PANCREAS_BETA_CELLS+0.350
  • ANDROGEN_RESPONSE+0.330
  • E2F_TARGETS+0.320
  • INTERFERON_GAMMA_RESPONSE+0.290
  • MYC_TARGETS_V1+0.290
  • OXIDATIVE_PHOSPHORYLATION+0.290
  • G2M_CHECKPOINT+0.250

Top 10 suppressed

  • WNT_BETA_CATENIN_SIGNALING-0.400
  • MYOGENESIS-0.350
  • TNFA_SIGNALING_VIA_NFKB-0.260
  • ALLOGRAFT_REJECTION-0.240
  • HEDGEHOG_SIGNALING-0.230
  • KRAS_SIGNALING_DN-0.220
  • APICAL_JUNCTION-0.210
  • APICAL_SURFACE-0.180
  • IL6_JAK_STAT3_SIGNALING-0.180
  • MYC_TARGETS_V2-0.180

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

6 twins match this tumor's tissue · 4 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1TCGA-D8-A1JT-01A-31R-A13Q-07
breast-umap@18
B0.821
2BS_TXZ7KHTQ
brain-umap@2
high-grade glioma0.820
39cdb8246-eedc-40e2-b340-52db1edd0838
colon-landscapes@1
0.804
4SJEPD031160_D1.RNA-Seq
medullo-epn-umap@date-based
EPNEPN Tumor0.802
5SRR25617939
breast-umap@18
B0.794
6SRR1797282
lung-landscapes@6
cohortSC0.789
7cb6e4e0c-6f89-4ea5-a89d-1b0da8cf7fac
colon-landscapes@1
0.788
8SRR1797281
lung-landscapes@6
cohortSC0.788
9BS_CZ3ER8DY
medullo-epn-umap@date-based
EPNSupratentorial EPN0.783
10BS_CZ3ER8DY
brain-umap@2
Supratentorial Ependymoma0.782

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 26 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
PROTEIN_SECRETION0.540Remibrutinib— uncovered
INTERFERON_ALPHA_RESPONSE0.450Inavolisib— uncovered
MTORC1_SIGNALING0.360Inavolisib— uncovered
PANCREAS_BETA_CELLS0.350Cobimetinib— uncovered
ANDROGEN_RESPONSE0.330Inavolisib— uncovered
E2F_TARGETS0.320Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.290Idelalisib— uncovered
MYC_TARGETS_V10.290Inavolisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.290Remibrutinib— uncovered
G2M_CHECKPOINT0.250Inavolisib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.240Idelalisib— uncovered
PEROXISOME0.230Idelalisib— uncovered
BILE_ACID_METABOLISM0.180Inavolisib— uncovered
ADIPOGENESIS0.170Inavolisib— uncovered
PI3K_AKT_MTOR_SIGNALING0.160Inavolisib— uncovered
SPERMATOGENESIS0.150Inavolisib— uncovered
FATTY_ACID_METABOLISM0.120Inavolisib— uncovered
GLYCOLYSIS0.120Inavolisib— uncovered
HEME_METABOLISM0.100Temsirolimus— uncovered
UV_RESPONSE_DN0.090Inavolisib— uncovered