Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-AR-A1AW-01A-21R-A12P-07

· D

b686a1d1-5a37-554b-a238-5dcfca86001a

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
D
subtype
D
overall_survival_months
88

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • INTERFERON_ALPHA_RESPONSE+0.710
  • INTERFERON_GAMMA_RESPONSE+0.700
  • ALLOGRAFT_REJECTION+0.640
  • IL6_JAK_STAT3_SIGNALING+0.500
  • INFLAMMATORY_RESPONSE+0.440
  • COMPLEMENT+0.350
  • IL2_STAT5_SIGNALING+0.280
  • G2M_CHECKPOINT+0.240
  • MITOTIC_SPINDLE+0.240
  • KRAS_SIGNALING_UP+0.190

Top 10 suppressed

  • OXIDATIVE_PHOSPHORYLATION-0.440
  • NOTCH_SIGNALING-0.410
  • GLYCOLYSIS-0.400
  • TGF_BETA_SIGNALING-0.380
  • ADIPOGENESIS-0.350
  • ESTROGEN_RESPONSE_EARLY-0.330
  • ESTROGEN_RESPONSE_LATE-0.330
  • CHOLESTEROL_HOMEOSTASIS-0.320
  • EPITHELIAL_MESENCHYMAL_TRANSITION-0.320
  • ANGIOGENESIS-0.310

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1AUR-AF95-TTP1-A-1-0-R-A741-41
breast-umap@18
D0.901
2C3N-02922
lung-landscapes@6
cohortMD20.891
3SRR8613787
breast-umap@18
D0.867
4SRR10842377
melanoma-umap@29
0.863
5BSR_11_0107_E3_S77
breast-umap@18
D0.861
6SRR8613734
breast-umap@18
D0.859
7BSR_02_0049_A5_S69
breast-umap@18
D0.856
8SRR25043622
head-neck@1
0.852
9TCGA-B6-A0RT-01A-21R-A084-07
breast-umap@18
D0.850
10SRR8518190
breast-umap@18
D0.847

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 16 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
INTERFERON_ALPHA_RESPONSE0.710Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.700Idelalisib— uncovered
ALLOGRAFT_REJECTION0.640Idelalisib— uncovered
IL6_JAK_STAT3_SIGNALING0.500Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.440Idelalisib— uncovered
COMPLEMENT0.350Inavolisib— uncovered
IL2_STAT5_SIGNALING0.280Idelalisib— uncovered
G2M_CHECKPOINT0.240Inavolisib— uncovered
MITOTIC_SPINDLE0.240Inavolisib— uncovered
KRAS_SIGNALING_UP0.190Inavolisib— uncovered
E2F_TARGETS0.180Inavolisib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.160Idelalisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.120Inavolisib— uncovered
HEME_METABOLISM0.070Temsirolimus— uncovered
PI3K_AKT_MTOR_SIGNALING0.070Inavolisib— uncovered
APOPTOSIS0.050Idelalisib— uncovered