SRR10842356

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b6b47534-acd5-5a94-9e1b-9962410deb52

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type: —
cancer_type_detailed: —
subtype: —

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

7 twins match this tumor's tissue · 3 come from a different tissue of origin

#	Sample	Cancer type	Subtype	cos similarity
1	TCGA-GM-A2DM-01A-11R-A180-07 breast-umap@18	—	B	0.745
2	ERR2208942 melanoma-umap@29	—	—	0.707
3	MDT-AP-2744 medullo-epn-umap@date-based	Med	Medulloblastoma	0.673
4	MDT-AP-2996 medullo-epn-umap@date-based	Med	Medulloblastoma	0.673
5	TCGA-86-8056-01A-11R-2241-07 lung-landscapes@6	—	cohortA1	0.656
6	BS_9M5XJ10G medullo-epn-umap@date-based	Med	Medulloblastoma	0.645
7	TCGA-CV-6953-01A-11R-1915-07 head-neck@1	—	—	0.643
8	SRR8518177 breast-umap@18	—	F	0.643
9	TCGA-J2-8194-01A-11R-2241-07 lung-landscapes@6	—	cohortA2	0.642
10	SRR8518157 breast-umap@18	—	F	0.642

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 19 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)	tumor score	Best drug	reversal magnitude
PROTEIN_SECRETION	0.400	Remibrutinib	— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY	0.300	Inavolisib	— uncovered
UNFOLDED_PROTEIN_RESPONSE	0.300	Idelalisib	— uncovered
ANDROGEN_RESPONSE	0.200	Inavolisib	— uncovered
ADIPOGENESIS	0.100	Inavolisib	— uncovered
APOPTOSIS	0.100	Idelalisib	— uncovered
COMPLEMENT	0.100	Inavolisib	— uncovered
DNA_REPAIR	0.100	Idelalisib	— uncovered
GLYCOLYSIS	0.100	Inavolisib	— uncovered
HEME_METABOLISM	0.100	Temsirolimus	— uncovered
HYPOXIA	0.100	Idelalisib	— uncovered
IL6_JAK_STAT3_SIGNALING	0.100	Inavolisib	— uncovered
KRAS_SIGNALING_UP	0.100	Inavolisib	— uncovered
P53_PATHWAY	0.100	Idelalisib	— uncovered
PEROXISOME	0.100	Idelalisib	— uncovered
PI3K_AKT_MTOR_SIGNALING	0.100	Inavolisib	— uncovered
TGF_BETA_SIGNALING	0.100	Inavolisib	— uncovered
TNFA_SIGNALING_VIA_NFKB	0.100	Inavolisib	— uncovered
UV_RESPONSE_UP	0.100	Idelalisib	— uncovered