Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

← Cohorts · mng-umap@100

MNG412

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b9555d4f-162b-5f59-b94c-31b2e76e2a26

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
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cancer_type_detailed
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subtype
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GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • MYC_TARGETS_V2+0.478
  • TNFA_SIGNALING_VIA_NFKB+0.413
  • CHOLESTEROL_HOMEOSTASIS+0.387
  • P53_PATHWAY+0.363
  • ANGIOGENESIS+0.340
  • HYPOXIA+0.315
  • DNA_REPAIR+0.258
  • REACTIVE_OXYGEN_SPECIES_PATHWAY+0.248
  • UV_RESPONSE_UP+0.231
  • MTORC1_SIGNALING+0.214

Top 10 suppressed

  • E2F_TARGETS-0.293
  • ALLOGRAFT_REJECTION-0.219
  • G2M_CHECKPOINT-0.214
  • SPERMATOGENESIS-0.200
  • INTERFERON_ALPHA_RESPONSE-0.181
  • PANCREAS_BETA_CELLS-0.174
  • INTERFERON_GAMMA_RESPONSE-0.164
  • PROTEIN_SECRETION-0.116
  • UV_RESPONSE_DN-0.114
  • IL6_JAK_STAT3_SIGNALING-0.109

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

6 twins match this tumor's tissue · 4 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1MNG754
mng-umap@100
——0.819
2SRR23303744
bladder-landscape@3
——0.762
3d25af392-21ad-4aa6-8669-34656bf71af5
colon-landscapes@1
——0.741
4GSM5359427
bladder-landscape@3
——0.714
5SJEPD001503_D1.RNA-Seq
medullo-epn-umap@date-based
EPNPosterior Fossa EPN0.713
6SRR1465917
brain-umap@2
GTEX—0.712
7MNG413
mng-umap@100
——0.711
8MBCProject_1151_T1_RNA
breast-umap@18
—B0.709
9BS_MA2T7ET1
brain-umap@2
Spinal Cord Ependymoma—0.708
10SRR1081741
brain-umap@2
GTEX—0.701

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 32 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
MYC_TARGETS_V20.478Idelalisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.413Inavolisib— uncovered
CHOLESTEROL_HOMEOSTASIS0.387Remibrutinib— uncovered
P53_PATHWAY0.363Idelalisib— uncovered
ANGIOGENESIS0.340Remibrutinib— uncovered
HYPOXIA0.315Idelalisib— uncovered
DNA_REPAIR0.258Idelalisib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.248Inavolisib— uncovered
UV_RESPONSE_UP0.231Idelalisib— uncovered
MTORC1_SIGNALING0.214Inavolisib— uncovered
APICAL_JUNCTION0.207Inavolisib— uncovered
APOPTOSIS0.190Idelalisib— uncovered
MYC_TARGETS_V10.186Inavolisib— uncovered
GLYCOLYSIS0.179Inavolisib— uncovered
ADIPOGENESIS0.172Inavolisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.146Remibrutinib— uncovered
MYOGENESIS0.137Inavolisib— uncovered
COAGULATION0.125Binimetinib— uncovered
HEME_METABOLISM0.123Temsirolimus— uncovered
PI3K_AKT_MTOR_SIGNALING0.123Inavolisib— uncovered